Actively Recruiting
129Xe Gas Exchange MRI to Visualize Cardiopulmonary Function
Led by Bastiaan Driehuys · Updated on 2026-02-04
125
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
B
Bastiaan Driehuys
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying biomarkers from 129Xe gas exchange MRI to understand how they change with different medical interventions. The study focuses on interactions between 129Xe and red blood cells in the lungs. Participants include healthy volunteers and patients with conditions like interstitial lung disease, pulmonary hypertension, acute or chronic pulmonary embolism, anemia, polycythemia, and dyspnea. The study uses hyperpolarized xenon gas inhaled in multiple doses followed by breath holds, alongside oxygen administration. Participants are grouped by treatment: those undergoing transfusion or phlebotomy, patients receiving oxygen for lung-related conditions or healthy volunteers, and those recently diagnosed with acute or chronic pulmonary embolism. Treatments and responses are monitored at baseline and various follow-up points. Participants will undergo MRI scans to measure red blood cell transfer, chemical shifts after oxygen delivery, and changes in red blood cell signal oscillations before and after treatment. The study includes visits up to 3–6 months after interventions to track changes. Researchers also monitor safety and participant adherence throughout the study, which lasts until mid-2028.
CONDITIONS
Brief Title
129Xe MRI Cardiopulmonary
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged over 18
- Willing and able to give informed consent and follow study visits and procedures
- Healthy volunteers with no diagnosed lung conditions, no smoking in the past 5 years, and minimal smoking history
- Patients scheduled for red cell transfusion or therapeutic phlebotomy for blood disorders
- Patients with physician-diagnosed interstitial lung disease or dyspnea
- Patients diagnosed with chronic thromboembolic pulmonary hypertension (CTEPH) scheduled for surgery
- Patients with acute pulmonary embolism within 24-48 hours post-admission
- Ability to return for follow-up visits 3-6 months after treatment when applicable
You will not qualify if you...
- Contraindication to MRI based on screening
- Pregnancy or breastfeeding
- Resting oxygen saturation below 90% despite supplemental oxygen
- Recent respiratory infection within 30 days
- History of ventricular cardiac arrhythmia or cardiac arrest in the past year
- Inability to fit into the MRI vest coil
- Inability to hold breath for at least 10 seconds
- Inability to follow imaging instructions
- Medical or psychological conditions posing undue risk or compliance issues
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 days around transfusion or phlebotomy; baseline and 1 day for oxygen administration; baseline and 3 to 6 months post-treatment for some groups
Participants undergo MRI scans using hyperpolarized xenon gas and oxygen administration to visualize cardiopulmonary function and assess red blood cell interactions in the lungs.
1 to 3 visits depending on treatment group and timing
Duration - 3 to 6 months
Participants are followed up to assess changes in red blood cell chemical shifts and oscillation amplitude after treatment.
1 follow-up visit
Trial Site Locations
Total: 1 location
1
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
Research Team
B
Bastiaan Driehuys, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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