Actively Recruiting
129Xe MRI Cardiopulmonary
Led by Bastiaan Driehuys · Updated on 2026-02-04
125
Participants Needed
1
Research Sites
233 weeks
Total Duration
On this page
Sponsors
B
Bastiaan Driehuys
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this NIH-sponsored study is to characterize three biomarkers derived from 129Xe gas exchange MRI and to understand how they change in response to interventions.
CONDITIONS
Official Title
129Xe MRI Cardiopulmonary
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older of any gender
- Willing and able to give informed consent and follow study procedures
- Healthy volunteers with no diagnosed lung conditions
- No smoking in the past 5 years and smoking history less than or equal to 5 pack-years
- No use of inhaled products more than once a week for over 1 year
- Patients scheduled for red blood cell transfusion for anemia or therapeutic phlebotomy for erythrocytosis or polycythemia
- Healthy volunteers donating whole blood
- Patients with interstitial lung disease, dyspnea, chronic thromboembolic pulmonary hypertension, or healthy volunteers able to participate
- Patients with acute pulmonary embolism 24-48 hours after admission, willing to return after 3-6 months
- Patients with chronic thromboembolic pulmonary hypertension scheduled for surgery and willing to return 3-6 months later for follow-up
You will not qualify if you...
- Contraindications to MRI
- Pregnancy or lactation
- Resting oxygen saturation below 90% even with supplemental oxygen
- Respiratory infection within 30 days before MRI
- History of ventricular cardiac arrhythmia
- History of cardiac arrest within the past year
- Physical size incompatible with MRI vest coil
- Inability to hold breath for 10 seconds
- Unlikely to comply with imaging instructions
- Medical or psychological conditions posing risk or interfering with study compliance
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
Research Team
B
Bastiaan Driehuys, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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