Actively Recruiting
18F-DOPA II - PET Imaging Optimization
Led by University of Alberta · Updated on 2026-02-09
800
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the optimization of 18F-DOPA PETCT imaging in specific patient groups including pediatric patients with congenital hyperinsulinism or neuroblastoma, pediatric and adult patients with neuroendocrine tumors or brain tumors, and adults suspected of Parkinsons disease or Lewy body dementia. The study aims to improve image quality using a new digital PETCT scanner and intravenous furosemide, while also exploring gallbladder activity patterns related to dopaminergic degeneration. Participants will receive an intravenous injection of 18F-DOPA, with some also receiving a single intravenous dose of furosemide. The study includes a primary objective of assessing image quality improvements in the pelvis area and a secondary objective examining gallbladder activity patterns using dynamic imaging in a subgroup. Imaging data will be compared to previous scans with older technology. During the study, participants will undergo PETCT scans, with measurements of lesion size and activity, bladder activity, and image artifact scoring. A questionnaire will screen for gallbladder disease history. The research team will analyze the imaging results and gallbladder activity patterns, with follow-up assessments occurring within one to three months. The total planned enrollment is 800 patients over approximately five years, with detailed monitoring of image optimization and gallbladder activity.
CONDITIONS
Brief Title
18F-DOPA II - PET Imaging Optimization
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pediatric patients under 18 years old with congenital hyperinsulinism
- Pediatric patients under 18 years old with neuroblastoma
- Pediatric (under 18) or adult patients (18 or older) with known or suspected neuroendocrine tumor
- Adult patients (18 or older) with clinical suspicion of Parkinson's disease or Lewy body dementia
- Pediatric (under 18) or adult patients (18 or older) with brain tumors
You will not qualify if you...
- Unable to provide consent
- Weight over 225 kg due to scanner limitations
- Adult patients unable to lie flat for 20-30 minutes during the PET/CT scan
- Pediatric patients under 13 years unable to lie flat for 20-30 minutes and for whom sedation is contraindicated
- Lack of intravenous access
- History of cholecystectomy (excluded from dynamic abdomen sub-study only)
- Pregnancy
Research Team
J
Jonathan Abele, MD
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