Actively Recruiting
18F-FAPI PET/MRI Imaging in Myelofibrosis: a Prospective Observational Study.
Led by First Affiliated Hospital of Zhejiang University · Updated on 2026-02-04
57
Participants Needed
1
Research Sites
162 weeks
Total Duration
On this page
Sponsors
F
First Affiliated Hospital of Zhejiang University
Lead Sponsor
Z
Zhejiang Provincial Tongde Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study intends to use a prospective, observational, self-controlled, multi-center study design to evaluate the feasibility and diagnostic efficacy of 18F-FDG PET/CT and 18F-FAPI PET/MRI imaging for the evaluation of systemic fibrosis in MF patients based on the results of bone marrow pathological biopsy, and to analyze the relationship between imaging results and clinical prognosis.
CONDITIONS
Official Title
18F-FAPI PET/MRI Imaging in Myelofibrosis: a Prospective Observational Study.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with primary myelofibrosis or myelofibrosis secondary to myeloid tumors according to WHO 2022 criteria
- Stable vital signs and ECOG score of 2 points or higher
- Able to tolerate and cooperate to complete 18F-FDG PET/CT and 18F-FAPI PET/MRI scans
- Interval between imaging, hematologic, cytogenetic, and pathology assessments is less than 2 weeks
- Willing to undergo 18F-FDG PET/CT and 18F-FAPI PET/MRI and provide informed consent
You will not qualify if you...
- Unable or unwilling to provide informed consent
- Diagnosed with other malignancies, autoimmune diseases, or chronic active infections within 1 year before MF diagnosis
- Current infection within 1 week before PET examination
- Pregnant or breastfeeding
- Unable to follow the study protocol for follow-up
- Received glucocorticoid therapy within 2 weeks before PET imaging
- Used granulocyte colony-stimulating factor (G-CSF) within 4 weeks before PET imaging
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310003
Actively Recruiting
Research Team
J
Jie Sun, MD，Ph.D
CONTACT
J
Jun Zhang, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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