Actively Recruiting
18F FDG and 68Ga FAPI PET/MR Imaging of Carotid Artery Plaque Vulnerability: A Clinical Study in Carotid Artery Plaque Patients
Led by Ruijin Hospital · Updated on 2026-03-05
100
Participants Needed
1
Research Sites
89 weeks
Total Duration
On this page
Sponsors
R
Ruijin Hospital
Lead Sponsor
N
National Natural Science Foundation of China
Collaborating Sponsor
AI-Summary
What this Trial Is About
Carotid atherosclerotic plaque rupture is the main cause of ischemic stroke attacks, and early and precise assessment of plaque vulnerability can prevent ischemic stroke. High-resolution MRI can reflect vulnerable plaque features such as thin fibrous caps and large lipid cores, but cannot assess their metabolic information; Fibro-activated proteins (FAPs) of PET are specifically expressed in atherosclerosis and suggest vulnerable plaques by reflecting inflammation-induced fibrosis. The aim of this study was to apply 18F FDG\&68Ga-FAPI PET/MR imaging to investigate the vulnerability of carotid atherosclerotic plaques, to obtain quantitative evaluation indexes of active fibrosis within carotid plaques, and to clarify the PET/MR characteristics of unstable plaques in carotid arteries
CONDITIONS
Official Title
18F FDG and 68Ga FAPI PET/MR Imaging of Carotid Artery Plaque Vulnerability: A Clinical Study in Carotid Artery Plaque Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years
- Presence of carotid atherosclerotic plaque confirmed by ultrasound within the past two weeks
- Carotid intima-media thickness (IMT) 6 2 mm (IMT 6 1.2 mm defines carotid atherosclerosis)
- Carotid artery stenosis 6 50% indicated by CTA
You will not qualify if you...
- Contraindications to PET/MR imaging safety (e.g., metallic implants, MRI phobia)
- Previous carotid endarterectomy (CEA) or carotid artery stenting (CAS)
- Pregnant or lactating women
- Other vascular diseases such as vasculitis, moyamoya disease, or arterial dissection
- Severe agitation or inability to cooperate with imaging procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China, 200025
Actively Recruiting
Research Team
J
JUN LIU Professor
CONTACT
B
BIN LIU PhD student
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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