Actively Recruiting
18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery
Led by Baptist Health South Florida · Updated on 2025-05-18
46
Participants Needed
1
Research Sites
159 weeks
Total Duration
On this page
Sponsors
B
Baptist Health South Florida
Lead Sponsor
B
Blue Earth Diagnostics
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a pilot imaging study in participants treated with stereotactic radiosurgery (SRS) to treat brain metastasis. The purpose of this study is to see whether 18F-Fluciclovine positron emission tomography (PET) can be used as a biomarker to measure response or progression of brain metastasis after SRS.
CONDITIONS
Official Title
18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of cancer with radiographic finding of brain metastasis
- Any number of brain metastasis, with all lesions 64 2 cm in maximum dimension
- Planned treatment with stereotactic radiosurgery (SRS) as per the treating physician team
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Individuals of reproductive potential must use two highly effective forms of contraception for at least 4 weeks prior to screening and during study participation up to 1 week after the last 18F-fluciclovine PET
You will not qualify if you...
- Prior anaphylactic reaction to 18F-fluciclovine
- Radiographic evidence of leptomeningeal disease
- Prior whole-brain radiation therapy
- Inability to undergo MRI (e.g., presence of pacemaker)
- Pregnant or positive serum pregnancy test within 14 days of registration
- Expecting to be breastfeeding at time of 18F-fluciclovine PET and unwilling to stop breastfeeding for 24 hours
- Major medical illness or psychiatric/cognitive impairments preventing protocol completion or informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Miami Cancer Institute
Miami, Florida, United States, 33176
Actively Recruiting
Research Team
R
Rupesh Kotecha, M.D.
CONTACT
A
Antoinette Pimental
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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