Actively Recruiting
A Study of 18F-MFBG Imaging for Tumor Burden and Diagnostic Performance in Pheochromocytoma, Paraganglioma, and Neuroblastoma
Led by Peking Union Medical College Hospital · Updated on 2024-03-01
150
Participants Needed
1
Research Sites
65 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the use of 18F-metafluorobenzylguanidine 18F-MFBG positron emission tomography PET to evaluate neuroendocrine tumors, mainly pheochromocytoma, paraganglioma PPGL, and neuroblastoma NB. These tumors express norepinephrine transporter NET, which is targeted by imaging substances like 123I131I-MIBG. However, current imaging methods have limitations such as low resolution and long waiting times, which affect diagnosis. This study aims to assess the safety, image quality, diagnostic accuracy, and tumor burden detection of 18F-MFBG PET in these neural crest tumors.
CONDITIONS
Brief Title
18F-MFBG PET/CT in the Evaluation of Neural Crest Tumor
Who Can Participate
Eligibility Criteria
You may qualify if you...
- The participant has read, signed, and dated an informed consent form before any study procedures.
- Patients have histologically confirmed or clinically suspected neural crest tumor.
- Neuroblastoma patients should have routine 123I-MIBG scintigraphy (planar + SPECT/CT) within 6 months before or scheduled within 3 months after the inclusion visit.
- Participants can be male or nonpregnant, nonlactating females who are surgically sterile or post-menopausal.
- Participants must be able and willing to comply with all study procedures as described in the protocol.
You will not qualify if you...
- Patients who are potentially pregnant or breastfeeding.
- Patients who undergo surgery between selection and inclusion visits.
- Patients who are pregnant, may become pregnant, or wish to become pregnant during the study period.
- Patients not suitable for trial participation according to researchers.
Research Team
P
Peipei Wang
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