Actively Recruiting
[18F]F-FAPI PET-CT to Identify Carcinoma of Unknown Primary Origin
Led by Erasmus Medical Center · Updated on 2025-02-12
50
Participants Needed
6
Research Sites
136 weeks
Total Duration
On this page
Sponsors
E
Erasmus Medical Center
Lead Sponsor
D
Dutch Cancer Society
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators will determine the proportion of CUP patients in whom the primary tumor can be identified by \[18F\]F-FAPI PET-CT.
CONDITIONS
Official Title
[18F]F-FAPI PET-CT to Identify Carcinoma of Unknown Primary Origin
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Histologically confirmed metastatic disease with no identified primary tumor after standard diagnostic work-up including at least an [18F]FDG PET-CT, following the national care pathway for CUP
You will not qualify if you...
- Known metastasis from a primary tumor that has already been identified
- Diagnosis of sarcomas, melanomas, germ cell tumors, neuroendocrine tumors, or hematological cancers without known origin
- History of cancer within 5 years before the PET-CT scan, except for the current cancer under study or cancers with very low risk of spread or death (e.g., treated carcinoma in-situ of cervix, nonmelanoma skin cancer, localized prostate cancer, ductal carcinoma in-situ, Stage I uterine cancer)
- Prior systemic therapy for CUP
- Radiotherapy before the PET-CT scan, except palliative radiotherapy for bone symptoms
- Poor kidney function with eGFR under 25 ml/min/1.73 m2 unless approved by treating doctor
- WHO performance status greater than 2
- Pregnancy or breastfeeding (temporary stopping breastfeeding may be considered)
- Known allergy to therapeutic radiopharmaceuticals
- Unable to lie still on back during PET-CT
- Any other medical condition or lab finding that could affect scan results or increase study burden, such as severe claustrophobia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Antoni van Leeuwenhoekziekenhuis
Amsterdam, Netherlands
Actively Recruiting
2
UMC Groningen
Groningen, Netherlands
Actively Recruiting
3
Maastricht UMC
Maastricht, Netherlands
Actively Recruiting
4
Radboud UMC
Nijmegen, Netherlands
Actively Recruiting
5
Erasmus Medical Center
Rotterdam, Netherlands
Actively Recruiting
6
UMC Utrecht
Utrecht, Netherlands
Actively Recruiting
Research Team
S
Sophie Veldhuijzen van Zanten, MD, PhD
CONTACT
E
Esther Droogers
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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