Actively Recruiting
24BRO681 : Alternating Gnp and mFOLFIRINOX for BR-PDAC
Led by Dartmouth-Hitchcock Medical Center · Updated on 2025-10-20
35
Participants Needed
1
Research Sites
195 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this research is to study the effects and safety of alternating neoadjuvant chemotherapy on borderline resectable pancreatic cancer.
CONDITIONS
Official Title
24BRO681 : Alternating Gnp and mFOLFIRINOX for BR-PDAC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 218 years or older
- Diagnosed with borderline resectable pancreatic adenocarcinoma confirmed by Dartmouth Cancer Center GI Tumor Board following NCCN Guidelines Version 2.2024
- Able and willing to provide informed consent
- Contrast-enhanced CT scan of chest, abdomen, and pelvis performed within 45 days before registration
- ECOG Performance Status of 0 to 1
- Females of childbearing potential must have a negative pregnancy test within 14 days before enrollment and agree to use effective contraception during treatment
You will not qualify if you...
- Previous chemotherapy or radiation therapy for pancreatic adenocarcinoma
- Known DPYD poor metabolizer genotype
- Known BRCA1/2 or PALB2 mutations (participants found with these mutations after enrollment will be removed from the study)
- Confirmed second malignancy likely to need systemic therapy during the study
- Baseline lab abnormalities including ANC < 2,500/mm3, platelet count < 100,000/mm3, hemoglobin < 7 g/dL, creatinine > 1.5 times upper normal limit, total bilirubin > 1.5 times upper normal limit, or AST/ALT > 5 times upper normal limit
- Peripheral sensory neuropathy impairing daily living activities
- Unable to provide informed consent
- Pregnant or breastfeeding
- Currently incarcerated
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
Research Team
C
Cancer Research Nurse
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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