What is this study trying to find out about heart failure?

This study aims to evaluate right ventricular function using 3D echocardiography in patients receiving a left ventricular assist device for heart failure. Researchers want to identify which patients are at higher risk for right ventricular failure after the procedure. The University of Alberta sponsors this research to improve understanding of heart function during LVAD implantation.

Who may be eligible for this heart failure clinical trial?

People aged 16 years or older who are scheduled to receive a left-sided HeartMate III, HeartWare HVAD, or Levitronix CentriMag LVAD may be eligible. The study accepts all genders and excludes those with missing heart imaging data or who have additional heart valve procedures planned. Please review eligibility criteria for more details.

Is there any cost to participate in this heart failure clinical trial?

Study-related care, including imaging and all trial visits, is provided at no cost. Personal travel and other expenses may vary and are not guaranteed to be covered. Participants can expect no charges for the study procedures themselves.

Actively Recruiting

Age: 16Years +

All Genders

Healthy Volunteers

ID05376254

Three-Dimensional Assessment of Right Ventricular Function in Patients Undergoing Left Ventricular Assist Device Implantation

Led by University of Alberta · Updated on 2026-05-29

200

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

The trial investigates the use of 3D transesophageal echocardiography TEE to analyze the right ventricles function in patients undergoing left ventricular assist device LVAD implantation. LVADs help support the left ventricle in patients with severe heart failure. Because right ventricular failure after LVAD implantation is common and linked to complications, this study aims to better predict which patients are at higher risk by using advanced 3D imaging methods. Participants receive one of several types of left-sided LVADs, including HeartMate III, HeartWare HVAD, or Levitronix CentriMag devices. During the LVAD implantation procedure, 3D TEE images of the right ventricle are taken and analyzed. The study focuses on gathering detailed heart function data and does not involve additional treatments or interventions beyond standard device implantation. During the study, researchers collect various heart function measurements within 24 hours after implantation, such as ventricular strain, volumes, ejection fractions, and tricuspid annular plane systolic excursion. Secondary outcomes include monitoring clinical data and lab tests over 14 days post-implantation. Participants are observed for right ventricular function and related support needs. The study started in March 2022 and will continue through January 2027, involving no experimental treatments beyond imaging and data collection.

CONDITIONS

Brief Title

3D Assessment of RV Function in Patients Undergoing LVAD Implantation

Who Can Participate

Age: 16Years +

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Patients receiving a left-sided HeartMate III LVAD
Patients receiving a left-sided HeartWare HVAD LVAD
Patients receiving a left-sided Levitronix CentriMag LVAD
Patients aged 16 years or older

You will not qualify if you...

Missing hemodynamic data needed to calculate pulmonary artery pulsatility index or comprehensive echocardiographic images
Additional heart valve repair or replacement during LVAD implantation (tricuspid, mitral, or aortic)
Inability to close the sternum at the end of the procedure
Right ventricular mechanical support introduced at the same time as LVAD implantation
Poor image quality preventing 3D imaging protocol
Known contraindication to transesophageal echocardiography (TEE)
Inability to advance the probe into the mid-esophagus for imaging

Research Team

Surita Sidhu, MD

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here