Actively Recruiting
3D Biomimetic Spine Unit Model Through the Integration of Bioprinting and Transcriptomics (CDP-SUBT)
Led by I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Updated on 2025-11-26
5
Participants Needed
1
Research Sites
99 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The general objective of this project is to define the transcriptional profile of primary human cells derived from the nucleus pulposus (NP), annulus fibrosus (AF), and cartilaginous endplate (CEP), and to use this information as a reference to assess the biological relevance of a biomimetic spinal unit model obtained through bioprinting. By developing an in vitro model of human origin that incorporates key components of the spinal unit and applying transcriptional analyses to both native cells and their counterparts recovered from the 3D construct, the study will evaluate how accurately the bioprinted model reproduces the identity and heterogeneity of the native discal environment.
CONDITIONS
Official Title
3D Biomimetic Spine Unit Model Through the Integration of Bioprinting and Transcriptomics (CDP-SUBT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed the Informed Consent for the study
- Age between 30 and 70 years
- Pfirrmann grade III to V of disc degeneration
- Need to undergo spinal surgery
You will not qualify if you...
- Presence of HIV infection
- Presence of hepatitis B virus infection
- Presence of hepatitis C virus infection
- Presence of syphilis infection (TPHA positive)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
IRCCS Ospedale Galeazzi-Sant'Ambrogio
Milan, MI, Italy, 20157
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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