3D Contrast Enhanced Ultrasound Imaging to Study Early Brain Injury and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage Using an Experimental Medical Device

What this Trial Is About

Aneurysmal subarachnoid hemorrhage (SAH) is a serious type of stroke with major complications including early brain injury, vasospasm, and delayed cerebral ischemia. These complications are typically monitored in neurocritical care settings using brain imaging methods like CT scans, MRI, and arteriography, which require moving critically ill patients within the hospital and can lead to complications. This research explores a new, non-invasive bedside device using 3D enhanced ultrasonography localizing microscopy to detect key arteries in the brain's anterior circulation, aiming to improve diagnosis and management of SAH complications. Participants with aneurysmal SAH involving the anterior circulation will receive standard care plus three bilateral transcranial enhanced ultrasonography exams using microbubble contrast (Sonovue) at three risk periods: days 0-2, 4-10, and 11-14. This investigational device is designed to provide detailed imaging comparable to angiography while being more accessible and safer by avoiding patient transport. The study plans to enroll 15 patients in a single-center feasibility pilot trial. During the study, researchers will assess the quality of blood flow signal captured by the ultrasonography through time-intensity curves of the contrast agent at each time point. They will also compare imaging findings with clinical outcomes. This bedside monitoring approach could allow earlier detection of complications like vasospasm or delayed ischemia without moving patients, potentially improving care. The trial includes assessments over two weeks and aims to gather initial data to support future larger studies.

3D Contrast Enhanced Acoustic Perfusion Imaging in Adult After Subarachnoid Hemorrhage