Evaluating 3D Magnetic Resonance Elastography for Measuring Meningioma Tumor Stiffness and Adhesion Compared to Surgery and Pathology

What this Trial Is About

Researchers are evaluating the use of three-dimensional magnetic resonance elastography 3D MRE to measure tumor stiffness and adhesion in patients with meningioma scheduled for surgical removal. This study aims to see if 3D MRE can serve as a noninvasive imaging tool to help surgeons plan operations, assess risks, and predict tumor behavior by comparing MRE findings with what surgeons observe during surgery and with pathological analysis after surgery. Participants will receive standard brain MRI along with additional 3D MRE scans before surgery. The 3D MRE uses vibrations and special software to create maps showing tumor stiffness and adhesion, which are shared with the neurosurgical team. During surgery, doctors will record tumor texture, adhesion, blood supply, and difficulty of removal to compare with the MRE results. Participants involvement includes preoperative MRI and MRE scans, surgery with detailed recording of tumor characteristics, and postoperative pathological analysis of tumor samples. Researchers will analyze how well MRE measurements match the surgical and histological findings. The main outcome is measuring agreement between MRE stiffness and tumor texture observed during surgery. The study is expected to continue until 2027, involving about 300 participants aged 18 to 80 years.

3D MRE-Based Evaluation of Meningioma Mechanical Properties and Histological Features