Actively Recruiting
3D OPTIMIZED WMN MPRAGE Increased Detection of Focal Spinal Cord Lesion in Multiple Sclerosis (WHINUME)
Led by University Hospital, Bordeaux · Updated on 2025-06-29
60
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare a new spinal cord imaging technique called the 3D OPTIMIZED WMN MPRAGE sequence with conventional MRI sequences for people with multiple sclerosis. Multiple sclerosis is a common inflammatory disease affecting the central nervous system, often causing spinal cord damage that leads to symptoms like sensory loss, pain, weakness, and bladder or bowel problems. Imaging the spinal cord is important for diagnosis and prognosis, but current methods have limitations in detecting lesions accurately. The study involves scanning patients at the cervical and thoracic levels of the spinal cord using both conventional MRI sequences (including 2D sagittal T2 FSE, 2D sagittal STIR, 2D sagittal PSIR, and 3D MPRAGE) and the new 3D OPTIMIZED WMN MPRAGE sequence. At the cervical level, the new sequence will be acquired in sagittal and axial views, while at the thoracic level it will be acquired sagittally. This comparison will help assess whether the new sequence provides better detection of spinal cord lesions. Participants will undergo MRI scans at one visit where researchers will evaluate the number and volume of lesions, presence of artifacts, contrast quality, and the relation of lesions to the patient's disability. The study will also measure sensitivity, positive predictive value, and reproducibility of the new imaging method. The total participation time corresponds to the imaging session on day one, with no long-term follow-up reported.
CONDITIONS
Brief Title
3D OPTIMIZED WMN MPRAGE Increased Detection of Focal Spinal Cord Lesion in Multiple Sclerosis (WHINUME)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients older than 18 years old
- Diagnosis of clinically isolated syndrome (CIS) or relapsing-remitting multiple sclerosis (RRMS)
- Spinal cord symptoms for less than 6 months
- With or without an objective lesion on a subsequent MRI
- Signed informed consent form
You will not qualify if you...
- Pregnant or potentially pregnant women
- Breastfeeding women
- Contraindications to MRI
- Other diagnoses such as neuro-myelitis spectrum disease or progressive multiple sclerosis
- History of surgery on the spinal cord or lumbar spine
- Patients under legal protection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo advanced spinal cord imaging using the 3D OPTIMIZED WMN MPRAGE sequence along with conventional MRI sequences to detect focal spinal cord lesions.
1 imaging visit (in-person)
Trial Site Locations
Total: 1 location
1
CHU de Bordeaux
Bordeaux, France
Actively Recruiting
Research Team
V
Vincent Dousset, MD, PhD
A
Amaury Ravache, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here