What is this study trying to find out about neuro-degenerative diseases?

This study aims to understand how deep brain stimulation (DBS) affects brain function in patients with neuro-degenerative and other neurological disorders. Researchers use advanced MRI techniques to observe brain activity and connectivity changes during DBS. This information may help improve DBS programming and patient care.

Who may be eligible for this neuro-degenerative disease clinical trial?

Adults between 18 and 85 years old who are planning to undergo or have undergone DBS electrode implantation may be eligible. Participants must be able to understand the study and communicate effectively in English. Those with serious cognitive impairments or communication difficulties may not qualify. Please review eligibility criteria for more details.

Is there any cost to participate in this neuro-degenerative disease clinical trial?

Study-related care, including the study scans and all trial visits, is provided at no cost. However, personal travel expenses to and from study visits may vary and are not guaranteed to be covered. Participants should plan accordingly for any travel costs.

Actively Recruiting

Phase Not Applicable

Age: 18Years - 85Years

All Genders

ID03153670

3T MRI in Patients With Deep Brain Stimulation DBS

Led by University Health Network, Toronto · Updated on 2024-05-08

250

Participants Needed

Research Sites

208 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are investigating the effects of deep brain stimulation DBS on brain function in patients with various neurological and psychiatric disorders, including Parkinsons disease, essential tremor, dystonia, depression, epilepsy, neuropathic pain, and Alzheimers disease. This prospective cohort study aims to use advanced MRI techniques, particularly functional MRI fMRI, to better understand how DBS influences brain circuits and to explore whether fMRI can aid clinical practice in managing DBS therapy. Participants in this study include patients who will undergo or have already undergone DBS electrode placement. The study involves performing structural MRI scans using 1.5 Tesla or 3 Tesla machines as well as resting state and task-based fMRI scans. DBS patients will be scanned while their devices are programmed at different stimulation settings, including switched off and switched on states. The fMRI results will be shared with clinicians to help guide DBS programming decisions. During the study, participants will have multiple brain scans from three months before DBS implantation to one year after. Researchers will assess brain areas activated by DBS, examine structural and functional brain connectivity through MRI, and monitor clinical outcomes. The study includes regular evaluations to observe how DBS impacts brain function over time, aiming to improve post-operative follow-up and optimize treatment for these patients.

CONDITIONS

Brief Title

3T MRI in Patients With Deep Brain Stimulation (DBS)

Who Can Participate

Age: 18Years - 85Years

All Genders

Eligibility Criteria

You may qualify if you...

Age between 18 and 85 years of age
Planned to undergo or have undergone implantation of DBS electrodes
Able to understand the purpose of the research and willing to sign informed consent
Understand that the study aims to enhance knowledge of brain function without direct personal benefit

You will not qualify if you...

Serious cognitive or psychological impairments preventing informed consent
Unable to communicate effectively or efficiently, including speech deficits or non-English speaking

Research Team

Alexandre Boutet, MD/MSc

Tasnuva Hoque, BHA

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