Predicting optimal deep brain stimulation parameters for Parkinson's disease using functional MRI and machine learning.
Alexandre Boutet, Radhika Madhavan, Gavin J B Elias...
https://pubmed.ncbi.nlm.nih.gov/34031407Actively Recruiting
Phase Not Applicable
Age: 18Years - 85Years
All Genders
ID03153670
3T MRI in Patients With Deep Brain Stimulation (DBS)
Led by University Health Network, Toronto · Updated on 2024-05-08
250
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the effects of deep brain stimulation (DBS) on brain function in patients with various neurological and psychiatric disorders, including Parkinson's disease, essential tremor, dystonia, depression, epilepsy, neuropathic pain, and Alzheimer's disease. This prospective cohort study aims to use advanced MRI techniques, particularly functional MRI (fMRI), to better understand how DBS influences brain circuits and to explore whether fMRI can aid clinical practice in managing DBS therapy. Participants in this study include patients who will undergo or have already undergone DBS electrode placement. The study involves performing structural MRI scans using 1.5 Tesla or 3 Tesla machines as well as resting state and task-based fMRI scans. DBS patients will be scanned while their devices are programmed at different stimulation settings, including switched off and switched on states. The fMRI results will be shared with clinicians to help guide DBS programming decisions. During the study, participants will have multiple brain scans from three months before DBS implantation to one year after. Researchers will assess brain areas activated by DBS, examine structural and functional brain connectivity through MRI, and monitor clinical outcomes. The study includes regular evaluations to observe how DBS impacts brain function over time, aiming to improve post-operative follow-up and optimize treatment for these patients.
CONDITIONS
Brief Title
3T MRI in Patients With Deep Brain Stimulation (DBS)
Who Can Participate
Age: 18Years - 85Years
All Genders
Eligibility Criteria
You may qualify if you...
- Age between 18 and 85 years of age
- Planned to undergo or have undergone implantation of DBS electrodes
- Able to understand the purpose of the research and willing to sign informed consent
- Understand that the study aims to enhance knowledge of brain function without direct personal benefit
You will not qualify if you...
- Serious cognitive or psychological impairments preventing informed consent
- Unable to communicate effectively or efficiently, including speech deficits or non-English speaking
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Imaging Visits
Duration - Up to 15 months covering 3 months before DBS implant to 1 year after DBS implant
Participants undergo MRI scans including structural and functional imaging with different DBS settings to evaluate brain responses.
Multiple MRI sessions depending on DBS implant timing and settings
Trial Site Locations
Total: 1 location
1
Toronto Western Hospital
Toronto, Ontario, Canada, M5T2S8
Actively Recruiting
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Research Team
A
Alexandre Boutet, MD/MSc
T
Tasnuva Hoque, BHA
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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