Actively Recruiting
Toward Precision Radiotherapy: Physiological Modeling of Respiratory Motion Using Ultra-quality 4D-MRI for Lung and Liver Cancer
Led by University of Virginia · Updated on 2026-05-06
100
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
Sponsors
U
University of Virginia
Lead Sponsor
D
Duke University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are developing advanced four-dimensional magnetic resonance imaging (4D-MRI) techniques to create detailed, moving images of the lungs and liver in adults. This imaging method produces three-dimensional movies that capture organ motion during breathing, which is important for improving radiation therapy planning for lung and liver cancer patients. The study aims to overcome challenges in current imaging methods to better target tumors that move with respiration. The study includes two main parts: technical development of ultra-quality 4D-MRI in healthy volunteers and evaluation of the technique in cancer patients. This involves creating a new MRI pulse sequence and image reconstruction process to achieve high spatial and temporal resolution with minimal motion artifacts. Researchers will compare the new 4D-MRI method to existing imaging and registration techniques in both healthy volunteers and patients with lung or liver tumors undergoing radiation therapy. Participants will undergo a single imaging session lasting up to two hours involving 4D-MRI scans. Healthy volunteers and cancer patients will be assessed to measure image quality and accuracy of motion modeling. The study will monitor how well the 4D-MRI technique captures tumor movement compared to current methods. The total participation time is limited to the imaging session, with no long-term follow-up mentioned.
CONDITIONS
Brief Title
4D-MRI for Precision Medicine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Lung or liver cancer patients aged 21 or older with tumors smaller than 7 cm
- Patients scheduled to receive radiation therapy including planning 4D-CT
- Healthy volunteers aged 18 or older
- Participants willing to comply with the 4D-MRI imaging protocol and provide informed consent
You will not qualify if you...
- Any condition preventing MRI use, such as non-MRI compatible metal implants
- Difficulty lying flat on the back for extended periods
- Serious or uncontrolled medical or psychological conditions affecting study compliance
- Body size too large for MRI machine or coils
- Claustrophobia
- Pregnant or lactating females
- Active or chronic infections
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 2 hours
Participants undergo a single imaging session using ultra-quality 4D-MRI to assess respiratory motion for precision radiotherapy planning.
1 visit (in-person)
Duration - Duration of radiotherapy treatment as per routine care
Participants may be observed for comparison of imaging techniques and motion models between 4D-MRI and standard methods during routine radiotherapy care.
Visit schedule depends on routine radiotherapy appointments
Trial Site Locations
Total: 1 location
1
University of Virginia
Charlottesville, Virginia, United States, 22908
Actively Recruiting
Research Team
R
Roselove N Nunoo-Asare, MA
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here