Actively Recruiting
4D-MRI for Precision Medicine
Led by University of Virginia · Updated on 2026-05-06
100
Participants Needed
1
Research Sites
529 weeks
Total Duration
On this page
Sponsors
U
University of Virginia
Lead Sponsor
D
Duke University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI). This technique produces three-dimensional movies of the inside of the chest and abdomen while the patient is breathing. (The fourth dimension is time!) This new way of medical imaging is being developed to help cancer patients undergoing radiation therapy. Radiation therapy is used to treat cancerous tumors. For radiation therapy to be effective, the precise size, shape, and location of the tumor within the body must be known. A particular difficulty for radiation treatment of lung and liver cancer is that the tumor moves during treatment because the patient is breathing. Therefore, tumor motion must also be incorporated into the treatment plan. This study aims to improve radiation treatment planning through better targeting and dose estimation based on 4D-MRI. Before this new imaging method can be used for radiation treatment planning, it must be tested in living, breathing volunteers.
CONDITIONS
Official Title
4D-MRI for Precision Medicine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- For lung and liver cancer patients: 21 years or older
- Have primary or metastatic tumors in the lungs or liver
- Tumor diameter less than 7 cm
- Scheduled to receive radiation therapy as part of treatment
- Will undergo planning CT scan with tumor motion assessment
- Signed informed consent and willing to follow 4D-MRI imaging protocol
- For healthy volunteers: 18 years or older
- Signed informed consent and willing to follow 4D-MRI imaging protocol
You will not qualify if you...
- Any condition that contraindicates MRI, including metal implants like pacemakers or non-MRI compatible clips
- Difficulty lying flat on back for extended time
- Serious or uncontrolled medical or psychological conditions that affect study compliance
- Body size too large to fit in the MRI machine or coils
- Claustrophobia
- Pregnant or breastfeeding females
- Active or chronic infections
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Virginia
Charlottesville, Virginia, United States, 22908
Actively Recruiting
Research Team
R
Roselove N Nunoo-Asare, MA
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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