Actively Recruiting
5HTP Regulation Of Asthma In Children
Led by Indiana University · Updated on 2026-03-02
20
Participants Needed
1
Research Sites
280 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to learn more about if taking a supplement called 5-hydroxytryptophan (5HTP) can improve breathing and anxiety symptoms related to asthma. To help learn more subjects will either be assigned to a group that is taking the supplement (5HTP) or a group that is taking a placebo. This will be decided randomly. Later in the study subjects will crossover to the other group.There are 5 study visits over the course of about 12 weeks.
CONDITIONS
Official Title
5HTP Regulation Of Asthma In Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 8 to 18 years
- Mild to moderate asthma based on ATS guidelines
- Positive allergy test (skin or serum IgE)
- Weight at least 70 lbs (32 kg)
- CES-DC score of 15 or higher or SCARED score of 25 or higher
- Ability to comply with study visits and procedures
- Informed consent by participant and parent or legal guardian if applicable
You will not qualify if you...
- Currently taking selective serotonin reuptake inhibitors (SSRIs)
- Taking leukotriene inhibitors such as montelukast or Zileuton
- Severe asthma based on ATS guidelines
- Taking biologic medications like omalizumab, mepolizumab, benralizumab, or dupilumab
- History of adverse reaction to 5HTP
- Physical findings that would compromise study safety or data quality
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Indiana University
Indianapolis, Indiana, United States, 46202
Actively Recruiting
Research Team
K
Kirsten Kloepfer, MD
CONTACT
P
Patrick Campbell, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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