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Study of How a Single Dose of Citalopram Affects Brain Response to Emotional Faces Using 7T fMRI in Adults Aged 18 to 40
Led by University of Oxford · Updated on 2025-02-21
50
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are investigating how the antidepressant citalopram affects the brains response to emotional information, focusing on the amygdala, a key brain area involved in depression. This study explores how different parts of the amygdala react to positive and negative emotional stimuli, using advanced brain scanning technology to understand the underlying brain mechanisms. Participants will receive a single oral dose of either 20 mg citalopram or a placebo in a randomized, double-blind design. After dosing, participants will undergo high-strength 7T fMRI brain scans while viewing emotional faces. This precise imaging allows researchers to observe how citalopram influences specific subfields of the amygdala during emotional processing. Participants will be screened for medical and psychiatric health before joining. During the study, brain activity and behavioral responses such as accuracy and reaction time during a gender discrimination task will be measured about three hours after dosing. The study includes safety monitoring and lasts for a few hours on the study day, focusing on neural and behavioral outcomes related to emotional processing.
CONDITIONS
Brief Title
7T Amygdala and Citalopram Study
Research Team
M
Marieke AG Martens, DPhil
C
Catherine J Harmer, DPhil
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