Actively Recruiting
90Y Transarterial Radioembolization Versus Microwave Ablation in Small Hepatocellular Carcinoma With Hypoalbuminemia
Led by Ochsner Health System · Updated on 2025-08-03
50
Participants Needed
1
Research Sites
177 weeks
Total Duration
On this page
Sponsors
O
Ochsner Health System
Lead Sponsor
B
Boston Scientific Corporation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial will compare 1-year outcomes in patients with hypoalbuminemia and a new diagnosis of small, early-stage hepatocellular carcinoma (HCC) who are candidates for both 90-Yittrium Therasphere transarterial radioembolization (90Y) and microwave ablation (MWA). The study will determine whether treatment with 90Y lowers the risk of disease progression within the first year after diagnosis. Participants will be randomized to receive either first cycle 90Y or MWA and then proceed with standard of care.
CONDITIONS
Official Title
90Y Transarterial Radioembolization Versus Microwave Ablation in Small Hepatocellular Carcinoma With Hypoalbuminemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of hepatocellular carcinoma (HCC) according to Liver Imaging - Reporting Data System (LI-RADS) criteria
- Eastern Cooperative Oncology Group (ECOG) performance score of 0 to 1
- Child-Pugh liver function class A or B
- Bilirubin level less than 2.5 mg/dL
- Creatinine level less than 2.0 mg/dL
- No prior liver-directed or systemic therapy for HCC
- Single unresectable HCC tumor 3 cm or smaller
- Albumin level less than 3.4 g/dL at diagnosis
- Tumor location suitable for both microwave ablation and 90Y treatment
You will not qualify if you...
- Pregnant women
- Presence of another active malignancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Ochsner Main Campus
New Orleans, Louisiana, United States, 70121
Actively Recruiting
Research Team
K
Ken Bode
CONTACT
A
Amy Riehm
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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