Study of 18F Fluorocholine PETCT Imaging for Patients With Suspected Parathyroid Adenoma and Negative or Unclear 99mTc Sestamibi SPECTCT Results

What this Trial Is About

Researchers are evaluating the use of a PET isotope called Fluorine-18 18F attached to Choline in people suspected of having parathyroid adenoma who have negative or unclear results from the standard 99mTc Sestamibi SPECTCT scan. The study focuses on detecting parathyroid adenomas using this new imaging technique in a single-center, single-arm trial. Participants receive an intravenous injection of 18F Fluorocholine about 5 mCi with a 20% margin, followed 45 to 60 minutes later by a low dose CT scan from the skull base to mid-thighs. This is immediately followed by a static PET emission scan over the same area, aiming to locate parathyroid adenomas more effectively than the standard scan. During the study, participants undergo the PETCT imaging process once, and researchers measure the number of lesions detected within an hour after the scan. Safety is monitored through blood tests and heart monitoring prior to the scan. The total participation time is brief and focused on imaging and related assessments.

99mTc Sestamibi SPECT/CT vs 18F Fluorocholine PET/CT