Status:

COMPLETED

Ocular Hypertension Treatment Study (OHTS)

Lead Sponsor:

Washington University School of Medicine

Collaborating Sponsors:

National Eye Institute (NEI)

Conditions:

Ocular Hypertension

Glaucoma

Eligibility:

All Genders

40-80 years

Phase:

PHASE3

Brief Summary

To determine whether medical reduction of intraocular pressure prevents or delays the onset of glaucomatous visual field loss and/or optic disc damage in ocular hypertensive participants judged to be ...

Detailed Description

OHTS Phase 3 will re-examine study participants 20 plus years after enrollment to document clinical status and the incidence and severity of self-reported functional limitations. The 279 participants ...

Eligibility Criteria

Men and nonpregnant women between the ages of 40 and 80 with IOP greater than or equal to 24 mm Hg but less than or equal to 32 mm Hg in at least one eye and IOP greater than or equal to 21 but less than or equal to 32 mm Hg in the fellow eye, as well as normal visual fields and optic discs are eligible for the trial. Patients presenting with best-corrected visual acuity worse than 20/40 in either eye, previous intraocular surgery, a life-threatening or debilitating disease, secondary causes of elevated IOP, angle-closure glaucoma or anatomically narrow angles, other diseases that can cause visual field loss, background diabetic retinopathy, optic disc abnormalities that can produce visual field loss or obscure the interpretation of the optic disc, or unwillingness to undergo random assignment are excluded from the trial.

Key Trial Info

Start Date :

February 1 1994

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

June 30 2019

Estimated Enrollment :

1636 Patients enrolled

Trial Details

Trial ID

NCT00000125

Start Date

February 1 1994

End Date

June 30 2019

Last Update

June 2 2020

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