Status:
COMPLETED
A Laboratory Model for Heroin Abuse Medications - 8
Lead Sponsor:
New York State Psychiatric Institute
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Heroin Dependence
Opioid-Related Disorders
Eligibility:
All Genders
18-45 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to evaluate the effects of treatment medications (methadone, buprenorphine, LAAM, naltrexone, naltrexone microcapsules, and methoclocinnamox) on I.V. and smoked heroin sel...
Detailed Description
Abuse of prescription opioid medications has increased dramatically in the U.S. during the past decade, as indicated by a variety of epidemiological sources. However, few studies have systematically e...
Eligibility Criteria
Inclusion Criterion
- DSM IV criteria for opioid dependence
- No major mood, psychotic, or anxiety disorder
- Physically healthy
- Able to perform study procedures
- 21-45 years of age
- Current use of i.v. heroin in amounts/frequencies
- Not seeking treatment for opioid dependence
Exclusion Criterion
- DSM IV criteria for dependence on drugs other
- Participants requesting treatment
- Participants on parole or probation
- Pregnancy or lactation
- Birth, miscarriage or abortion with 6 months
- Recent history of or current significant violent behavior
- Current major Axis I psychopathology, other than heroin dependence ( e.g., mood disorder with functional impairment or suicide risk, schizophrenia), which might interfere with ability to participate in the study
- Hepatitis with SGOT or SGPT > 3 times normal
- Significant suicide risk
- Current or history of chronic pain
- Sensitivity, allergy, or contraindication to opioids
Key Trial Info
Start Date :
August 1 1995
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2005
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT00000273
Start Date
August 1 1995
End Date
November 1 2005
Last Update
July 5 2017
Active Locations (2)
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1
Columbia University
New York, New York, United States, 10032
2
New York State Psychiatric Institute
New York, New York, United States, 10032