Status:
COMPLETED
Acute Withdrawal From Smoked Cocaine - 9
Lead Sponsor:
National Institute on Drug Abuse (NIDA)
Collaborating Sponsors:
University of Minnesota
Conditions:
Cocaine-Related Disorders
Substance Withdrawal Syndrome
Eligibility:
All Genders
21-45 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to develop an experimental paradigm to examine acute withdrawal symptoms from cocaine.
Detailed Description
Although there are clearly identifiable withdrawal syndromes following cessation of a number of abused drugs such as alcohol and heroin, it is unclear whether a withdrawal syndrome follows the cessati...
Eligibility Criteria
Inclusion Criteria:
M/F ages 21-45 with a history of smoked cocaine use at least twice a week for the past six months, including 0.5 g of cocaine in a 24hr period on at least one occasion. In good health as evidenced by physical exam and complete blood count, chest X-ray and electrolyte and liver function tests, with a normal resting 12-lead electrocardiograph (ECG) and blood pressure of less than 140/90 mmHg. Using an acceptable method of birth control. Having a urine toxicology screen positive for cocaine metabolites.
Exclusion Criteria:
Any DSM-IV Axis I disorder other than cocaine abuse or dependence, or dependence or daily use of psychoactive drugs other than nicotine or caffeine. A history of violence and/or currently on probation, parole or awaiting trial. Pregnant as determined by serum pregnancy screen, lactating or having delivered a child in the past 12 months. Seropositive tests for the human immunodeficiency virus (HIV) or hepatitis B. History of seizure disorder.
Key Trial Info
Start Date :
April 1 1996
Trial Type :
INTERVENTIONAL
End Date :
December 1 2001
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00000292
Start Date
April 1 1996
End Date
December 1 2001
Last Update
January 12 2017
Active Locations (1)
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1
University of Minnesota
Minneapolis, Minnesota, United States, 55455