Status:
COMPLETED
Trial of D-Cycloserine in Schizophrenia
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Schizophrenia
Eligibility:
All Genders
18-65 years
Phase:
PHASE3
Brief Summary
To characterize further the effects of D-cycloserine augmentation of antipsychotic treatment on negative symptoms, performance on neurocognitive tasks, and on markers for glutamatergic, dopaminergic a...
Detailed Description
To characterize further the effects of D-cycloserine augmentation of antipsychotic treatment on negative symptoms, performance on neurocognitive tasks, and on markers for glutamatergic, dopaminergic, ...
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of Schizophrenia as per DSM IV criteria
- Have been treated for at least 6 months with any conventional neuroleptic
- Have prominent negative symptoms as defined by a total score of 40 or greater on the scale for the assessment of negative symptoms (SANS)
Exclusion Criteria:
- Active alcohol or drug abuse
- Unstable Medical Illness, seizure disorder, or other serious neurological disorder
- Pregnant or Nursing
- Unable to complete a cognitive battery
Key Trial Info
Start Date :
August 1 1996
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2002
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00000371
Start Date
August 1 1996
End Date
April 1 2002
Last Update
September 10 2014
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