Status:
WITHDRAWN
Glycine and D-Cycloserine in Schizophrenia
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Schizophrenia
Eligibility:
All Genders
18-65 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to compare the effects of D-cycloserine and glycine for treating negative symptoms (such as loss of interest, loss of energy, loss of warmth, and loss of humor) which occu...
Detailed Description
To determine if glycine produces improvement in negative symptoms and D-cycloserine produces worsening in symptoms compared to placebo, patients will undergo a double blind study of d-cycloserine and ...
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of Schizophrenia
- Score of 27 or greater on the Scale for the Assessment of Negative Symptoms (SANS)
- Treatment with stable dose of clozapine for at least 4 weeks
- Between 18 and 65 years old
Exclusion Criteria:
- No other antipsychotic medications in oral for for at least 3 months or in depot form for 6 months
- Current major depressive episode
- Current substance abuse diagnosis
Key Trial Info
Start Date :
March 1 1998
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2005
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00000372
Start Date
March 1 1998
End Date
November 1 2005
Last Update
June 12 2014
Active Locations (1)
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1
Freedom Trail Clinic
Boston, Massachusetts, United States, 02114