Status:
COMPLETED
Antifolate Effectiveness in Arthritis
Lead Sponsor:
University of Alabama at Birmingham
Collaborating Sponsors:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Office of Dietary Supplements (ODS)
Conditions:
Rheumatoid Arthritis
Adjuvant Arthritis
Eligibility:
All Genders
18-85 years
Phase:
PHASE2
Brief Summary
This study looks at how the arthritis drug methotrexate works in low doses to treat rheumatoid arthritis. (High doses of methotrexate are used to treat some types of cancer.) Methotrexate blocks the a...
Detailed Description
Low-dose methotrexate therapy suppresses autoimmune arthritis in human and animal models. We hypothesize that the effect of methotrexate in the treatment of rheumatoid arthritis is due to the inhibiti...
Eligibility Criteria
Inclusion Criteria:
- Individuals starting methotrexate for rheumatoid arthritis.
- Study subjects should not currently be taking folic acid-containing vitamins.
Exclusion Criteria:
- Cancer, renal, or liver disease.
- Previous use of methotrexate within the past 6 months or current use of folic acid-containing supplements.
Key Trial Info
Start Date :
September 1 1996
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2002
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00000395
Start Date
September 1 1996
End Date
August 1 2002
Last Update
December 16 2016
Active Locations (1)
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1
The University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294