Effects of teriparatide retreatment in osteoporotic men and women.
Joel S Finkelstein, Jason J Wyland, Benjamin Z Leder...
https://pubmed.ncbi.nlm.nih.gov/19401368Completed
Phase 2
Age: 45Years - 85Years
All Genders
ID00000400
Bone Formation-Resorption Coupling and Osteoporosis
Led by Massachusetts General Hospital · Updated on 2013-12-09
176
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
N
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study looks at the effects of two medications, alendronate and parathyroid hormone, on bone mass and on bone formation and bone breakdown in women with osteoporosis. We will randomly select postmenopausal women who have osteoporosis to receive laboratory-produced human parathyroid hormone (hPTH), or alendronate, or both for 2.5 years. Study participants will return to the study center periodically to have their bone mass measured and to give blood and urine samples for tests of bone formation and breakdown and for other laboratory tests. Those who complete the study are eligible for one or two 12 month extension studies.
CONDITIONS
Official Title
Alendronate and/or Parathyroid Hormone for Osteoporosis
Who Can Participate
Age: 45Years - 85Years
All Genders
Eligibility Criteria
You may qualify if you...
- Lumbar spine or hip BMD T-score less than or equal to minus 2.0
- Postmenopausal at least 5 years
- Fully ambulatory
- Able to give informed consent
You will not qualify if you...
- No concurrent illnesses that cause bone loss
- No recent drug treatment for osteoporosis
- No recent fracture
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Status Unknown
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How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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