Completed
Phase 3
Age: 35Years - 59Years
MALE
ID00000488
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2016-04-14
N/A
Participants Needed
N/A
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
To determine whether reduction of cholesterol by drug therapy significantly lowered the atherosclerotic coronary heart disease rate in a group of hypercholesterolemic but otherwise healthy men. Total dollars spent on the CPPT from June 1973 were $142,250,000. We do not have a year-by-year breakdown.
CONDITIONS
Official Title
Lipid Research Clinics Coronary Primary Prevention Trial (CPPT)
Who Can Participate
Age: 35Years - 59Years
MALE
Eligibility Criteria
You may qualify if you...
Men, ages 35-59. Type II hyperlipoproteinemia. Free from coronary heart disease.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Site Locations not provided
Location information for this trial is currently unavailable.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
N/A
Primary Purpose
PREVENTION
Number of Arms
0
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Published Research Related To This Trial
Recruitment for the Coronary Primary Prevention Trial.
W S Agras, G Marshall
https://pubmed.ncbi.nlm.nih.gov/373955Recruitment for clinical trials: the Lipid Research Clinics Coronary Primary Prevention Trial experience. Its implications for future trials.
https://pubmed.ncbi.nlm.nih.gov/7127710Dietary determinants of plasma cholesterol change in the recruitment phase of the Lipid Research Clinics Coronary Primary Prevention Trial.
D J Gordon, K M Salz, K J Roggenkamp...
https://pubmed.ncbi.nlm.nih.gov/7181738Habitual physical activity and high-density lipoprotein cholesterol in men with primary hypercholesterolemia. The Lipid Research Clinics Coronary Primary Prevention Trial.
D J Gordon, J L Witztum, D Hunninghake...
https://pubmed.ncbi.nlm.nih.gov/6821893Pre-entry characteristics of participants in the Lipid Research Clinics' Coronary Primary Prevention Trial.
https://pubmed.ncbi.nlm.nih.gov/6863470The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease.
https://pubmed.ncbi.nlm.nih.gov/6361299The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering.
https://pubmed.ncbi.nlm.nih.gov/6361300Lipid Research Clinics Coronary Primary Prevention Trial: results and implications.
B M Rifkind
https://pubmed.ncbi.nlm.nih.gov/6382999Coronary risk factors and exercise test performance in asymptomatic hypercholesterolemic men: application of proportional hazards analysis.
D J Gordon, J L Probstfield, C Rubenstein...
https://pubmed.ncbi.nlm.nih.gov/6465119