Systolic hypertension in the elderly program (SHEP). The first three months.
S B Hulley, D Feigal, C Ireland...
https://pubmed.ncbi.nlm.nih.gov/3511131Completed
Phase 3
Age: 60Years - 100Years
All Genders
ID00000514
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2016-04-15
N/A
Participants Needed
N/A
Research Sites
N/A
Total Duration
On this page
Sponsors
N
National Heart, Lung, and Blood Institute (NHLBI)
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The primary objective was to assess whether long-term administration of antihypertensive therapy to elderly subjects with isolated systolic hypertension reduced the combined incidence of fatal and non-fatal stroke. The secondary objectives were to evaluate: the effect of long-term antihypertensive therapy on mortality from any cause in elderly people with isolated systolic hypertension; possible adverse effects of chronic use of antihypertensive drug treatment in this population; the effect of therapy on indices of quality-of-life; the natural history of isolated systolic hypertension in the placebo population.
CONDITIONS
Official Title
Systolic Hypertension in the Elderly Program (SHEP)
Who Can Participate
Age: 60Years - 100Years
All Genders
Eligibility Criteria
You may qualify if you...
Men and women, aged 60 or over, with isolated systolic hypertension.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Site Locations not provided
Location information for this trial is currently unavailable.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
N/A
Primary Purpose
PREVENTION
Number of Arms
0
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Published Research Related To This Trial
Rationale and design of a randomized clinical trial on prevention of stroke in isolated systolic hypertension. The Systolic Hypertension in the Elderly Program (SHEP) Cooperative Research Group.
https://pubmed.ncbi.nlm.nih.gov/2905387The Systolic Hypertension in the Elderly Program (SHEP): an intervention trial on isolated systolic hypertension. SHEP Cooperative Research Group.
J L Probstfield, W B Applegate, N O Borhani...
https://pubmed.ncbi.nlm.nih.gov/2676266The systolic hypertension in the elderly program. Implications for nursing practice and research.
E B Schron, J A Davey, J M Jensen...
https://pubmed.ncbi.nlm.nih.gov/2690065Echocardiographic evaluation of cardiac structure and function in elderly subjects with isolated systolic hypertension.
A C Pearson, C Gudipati, D Nagelhout...
https://pubmed.ncbi.nlm.nih.gov/1825095Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
https://pubmed.ncbi.nlm.nih.gov/2046107Prevalence of postural hypotension at baseline in the Systolic Hypertension in the Elderly Program (SHEP) cohort.
W B Applegate, B R Davis, H R Black...
https://pubmed.ncbi.nlm.nih.gov/1753042Systolic Hypertension in the Elderly Program (SHEP). Part 1: Rationale and design.
N O Borhani, W B Applegate, J A Cutler...
https://pubmed.ncbi.nlm.nih.gov/1999373Systolic Hypertension in the Elderly Program (SHEP). Part 2: Screening and recruitment.
H Petrovitch, R Byington, G Bailey...
https://pubmed.ncbi.nlm.nih.gov/1999371Systolic Hypertension in the Elderly Program (SHEP). Part 3: Sociodemographic characteristics.
T M Vogt, E Schron, S Pressel...
https://pubmed.ncbi.nlm.nih.gov/1999374