Trial of Calcium for Preeclampsia Prevention (CPEP): rationale, design, and methods.
R J Levine, J R Esterlitz, E G Raymond...
https://pubmed.ncbi.nlm.nih.gov/8932976Completed
Phase 3
Age: 18Years - 40Years
FEMALE
ID00000534
Led by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Updated on 2017-03-13
N/A
Participants Needed
N/A
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
To evaluate the efficacy of 2 grams per day of oral calcium supplementation in reducing the combined incidence of hypertensive disorders of pregnancy: pre-eclampsia, eclampsia, and the HELLP Syndrome (hypertension, thrombocytopenia, hemolysis, and abnormal liver function). The National Institute of Child Health and Human Development (NICHD) initiated the trial in 1991, with joint funding provided by the National Heart, Lung, and Blood Institute in fiscal years 1992, 1993, and 1995.
CONDITIONS
Official Title
Calcium for Pre-Eclampsia Prevention (CPEP)
Who Can Participate
Age: 18Years - 40Years
FEMALE
Eligibility Criteria
You may qualify if you...
Nulliparous, normotensive, pregnant women.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Site Locations not provided
Location information for this trial is currently unavailable.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
N/A
Model
N/A
Primary Purpose
PREVENTION
Number of Arms
0
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Published Research Related To This Trial
Risk factors associated with preeclampsia in healthy nulliparous women. The Calcium for Preeclampsia Prevention (CPEP) Study Group.
B M Sibai, M Ewell, R J Levine...
https://pubmed.ncbi.nlm.nih.gov/9396883Prostacyclin and thromboxane changes predating clinical onset of preeclampsia: a multicenter prospective study.
J L Mills, R DerSimonian, E Raymond...
https://pubmed.ncbi.nlm.nih.gov/10432033The relationship between abnormal glucose tolerance and hypertensive disorders of pregnancy in healthy nulliparous women. Calcium for Preeclampsia Prevention (CPEP) Study Group.
G M Joffe, J R Esterlitz, R J Levine...
https://pubmed.ncbi.nlm.nih.gov/9790393Trial of calcium to prevent preeclampsia.
R J Levine, J C Hauth, L B Curet...
https://pubmed.ncbi.nlm.nih.gov/9211675