Completed

Phase 3
Age: 55Years - 100Years
All Genders
ID00000542

Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2016-07-29

N/A

Participants Needed

N/A

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

To determine if the combined incidence of nonfatal myocardial infarction and coronary heart disease death differs between diuretic-based and each of three alternative antihypertensive pharmacological treatments. Also, to determine, in a subset of this population, if lowering serum cholesterol with a HMG CoA reductase inhibitor in older adults reduces all-cause mortality compared to a control group receiving usual care. Conducted in conjunction with the Department of Veterans' Affairs.

CONDITIONS

Official Title

Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

Who Can Participate

Age: 55Years - 100Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

Men and women hypertensive patients, ages 55 and above. A total of 36 percent were diabetics.

Not Eligible

You will not qualify if you...

History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety

Trial Site Locations

Site Locations not provided

Location information for this trial is currently unavailable.

How is the study designed?

Study Type

INTERVENTIONAL

Masking

N/A

Allocation

RANDOMIZED

Model

N/A

Primary Purpose

PREVENTION

Number of Arms

0

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Published Research Related To This Trial

Experimental approaches to determining the choice of first-step therapy for patients with hypertension. The ALLHAT Research Group Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.

P K Whelton, J D Williamson, G T Louis...

https://pubmed.ncbi.nlm.nih.gov/8743044

ALLHAT: the largest and most important clinical trial in hypertension ever done in the USA. Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial.

W J Elliott

https://pubmed.ncbi.nlm.nih.gov/8722446

Recruitment of African-American patients for clinical trials--the Allhat challenges. Antihypertensive and Lipid-lowering Trial to Prevent Heart Attack.

E Saunders

https://pubmed.ncbi.nlm.nih.gov/7674359

Rationale and design for the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). ALLHAT Research Group.

B R Davis, J A Cutler, D J Gordon...

https://pubmed.ncbi.nlm.nih.gov/8722437