Inclusion Criteria

Concurrent Medication: Included:

Pneumocystis carinii pneumonia prophylaxis (other than sulfamethoxazole alone or in combination with other medications).

• Antifungal prophylaxis with oral fluconazole or ketoconazole.
• Antiviral prophylaxis with a maximum of 1 g/day oral acyclovir.

Patients must have the following:

• HIV infection.
• Ability to voluntarily provide written informed consent prior to treatment.
• Willing and able to follow protocol requirements.
• Patients with nonvisceral Kaposi's sarcoma or with visceral Kaposi's sarcoma not requiring chemotherapy and/or irradiation may be included.

Exclusion Criteria

Co-existing Condition:

Patients with the following conditions or symptoms are excluded:

• Radiographic evidence of chronic pulmonary disease.
• Cytomegalovirus disease.
• Toxoplasmosis encephalitis requiring suppressive therapy.
• Mycobacteriosis requiring maintenance chemotherapy.
• Visceral Kaposi's sarcoma requiring chemotherapy and/or irradiation.

Concurrent Medication:

Excluded:

• Glucocorticoids and steroid hormones (including oral contraceptives).
• Dicumarol, warfarin, and other anticoagulant medications.
• Nitroglycerin.
• Digitoxin.
• Valproic acid.
• Tolbutamide.
• Doxycycline.
• Chloramphenicol.
• Isoniazid.
• Antiepileptics (Phenobarbital and other barbiturates).
• Sulfonamides.

Excluded for up to 4 hours before and 4 hours after administration of drug 2:

• Antacids.
• Cimetidine.
• Carafate.
• Cholestyramine resin.
• Alcohol and alcohol-containing substances.
• Benzodiazepines (diazepam, triazolam).

Patients with the following are excluded:

• History of clinically important disease (defined as a disease that, in the opinion of the investigator, may either put the patient at risk because of participation in the study or a disease that may influence the results of the study or the patient's ability to participate in the study) other than HIV infection.
• Malignancy other than Kaposi's sarcoma or limited cutaneous basal cell carcinoma.

Prior Medication:

Excluded within 4 weeks prior to administration of study drug 2:

• Antiretroviral (other than zidovudine (AZT)), immunosuppressive, or cytotoxic drugs.
• Glucocorticoids and steroid hormones (including oral contraceptives).
• Dicumarol, warfarin, and other anticoagulant medications.
• Nitroglycerin.
• Digitoxin.
• Valproic acid.
• Tolbutamide.
• Doxycycline.
• Chloramphenicol Isoniazid.
• Antiepileptics (Phenobarbital and other barbiturates).
• Sulfonamides.