Inclusion Criteria

• Detectable HIV nucleic acid in patient peripheral blood mononuclear leukocytes (PBML's) by the gene amplification technique. A positive antibody to HIV confirmed by any federally licensed ELISA test kit.

Concurrent Medication:

Allowed:

• Medications without which there might be significant risk, such as seizures, loss of diabetic control or respiratory embarrassment.
• Necessary topical agents including topical acyclovir.
• Diuretics for significant fluid retention only.

Concurrent Treatment:

Allowed:

• Blood transfusions for anemia if hematocrit falls below 25 percent.

Exclusion Criteria

• Active drug or alcohol abuse.

Co-existing Condition:

Patients with the following will be excluded:

• Grade 1 impairment on two or more items in the ACTG Micro Neuro AIDS assessment.
• Concurrent neoplasms other than basal cell carcinoma of the skin or in situ carcinoma of the cervix.
• Major organ allograft.
• Significant cardiac disease or central nervous system lesions.
• Patients with hemophilia should be evaluated and treated under the hemophilia protocol.

Concurrent Medication:

Excluded:

• Inderal or vasoactive hypertensive medication.
• Non-essential medications including pain medications.

Excluded are:

• Patients with an opportunistic infection or malignancy fulfilling the definition of AIDS.

Patients with AIDS related complex, defined as:

• 1. Weight loss in excess of 15 lbs. or 10 percent of body weight noted in a 2-year period prior to entry into the study. 2. Temperature greater than 38.5 degrees C with or without night sweats, persisting for more than 14 consecutive days or more than 15 days in a 30-day interval during a 2-year period prior to entry into the study. 3. Diarrhea defined as = or > 3 liquid stools per day, persisting for more than 30 days during a 2-year period prior to entry into the study without a definable cause. 4. Herpes zoster during the past 2 years. 5. Oral candidiasis or biopsy-proven hairy leukoplakia during the last 2 years. 6. Active substance abuse.

Prior Medication:

Excluded:

• Zidovudine (AZT).
• Excluded within 30 days of study entry:
• Antiretroviral agents.
• Biologic response modifiers.
• Corticosteroids.
• Excluded within 60 days of study entry:
• Ribavirin.