Inclusion Criteria

Required:

• At least 28 days of prior foscarnet or ganciclovir.

Concurrent Medication:

Allowed:

• G-CSF.

Recommended:

• Antiretroviral therapy.

Patients must have:

• HIV infection or AIDS.
• Active CMV retinitis after 28 or more days of either foscarnet or ganciclovir therapy.
• At least one lesion with one-quarter disk area or more that can be photographed.
• Visual acuity of 3 or more letters on ETDRS chart (5/200 Snellen) in an affected eye.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms and conditions are excluded:

• Media opacity severe enough to preclude visualization of both fundi.
• Retinal detachment not scheduled for surgical repair.

Patients with the following prior conditions are excluded:

• History of intolerance to ganciclovir or foscarnet sufficient to contraindicate use.
• History of combination foscarnet/ganciclovir therapy.

Active drug or alcohol abuse sufficient to prevent compliance.