Inclusion Criteria

Patients must have:

• Documented HIV infection.
• CD4 count 100 - 500 cells/mm3.
• No active opportunistic infection or wasting syndrome.
• Opiate addiction or prior enrollment in a methadone treatment program (methadone recipients only).
• Admission to General Clinical Research Center at Yale-New Haven Hospital for clonidine detoxification (methadone recipients only).

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

• Inadequate IV access.
• Benzodiazepine abuse.

Concurrent Medication:

Excluded:

• Amiodarone.
• Anesthetics, general.
• Azithromycin.
• Barbiturates.
• Carbamazepine.
• Cimetidine.
• Ciprofloxacin.
• Clarithromycin.
• Dexamethasone.
• Disulfiram.
• Erythromycin.
• Fluoroquinolones.
• Fluoxetine.
• Gestodene.
• Hydrochlorothiazide.
• Hypoglycemics, oral.
• Isoniazid.
• Itraconazole.
• Ketoconazole.
• Levomepromazine.
• MAO inhibitors.
• Methoxsalen.
• Nafcillin.
• Narcotic analgesics.
• Naringenin.
• Norethindrone.
• Omeprazole.
• Pentazocine.
• Phenothiazines.
• Phenytoin.
• Quinidine.
• Ranitidine.
• Rifabutin.
• Rifampin.
• Sedative Hypnotics.
• Sulfaphenazole.
• Tranquilizers (except at discretion of investigator and protocol chair).
• Tricyclic antidepressants.
• Troleandomycin.
• Warfarin.

Prior Medication:

Excluded within 4 weeks prior to study entry:

• Rifampin or its derivatives.
• Phenytoin.
• Barbiturates.
• Cimetidine.
• Other drugs known to induce or inhibit hepatic microsomal enzymes.

Excluded within 14 days prior to study entry:

• Any other experimental drug.
• Drugs with known nephrotoxic potential.

Excluded within 72 hours prior to study entry:

• Amiodarone.
• Anesthetics, general.
• Azithromycin.
• Carbamazepine.
• Ciprofloxacin.
• Clarithromycin.
• Dexamethasone.
• Disulfiram.
• Erythromycin.
• Fluoroquinolones.
• Fluoxetine.
• Gestodene.
• Hydrochlorothiazide.
• Hypoglycemics, oral.
• Isoniazid.
• Itraconazole.
• Ketoconazole.
• Levomepromazine.
• MAO inhibitors.
• Methoxsalen.
• Nafcillin.
• Narcotic analgesics.
• Naringenin.
• Norethindrone.
• Omeprazole.
• Pentazocine.
• Phenothiazines.
• Quinidine.
• Ranitidine.
• Rifabutin.
• Sedative Hypnotics.
• Sulfaphenazole.
• Tranquilizers (except at discretion of investigator and protocol chair).
• Tricyclic antidepressants.
• Troleandomycin.
• Warfarin.

Continued active drug or alcohol abuse or dependence that would decrease the probability of study completion.