Status:

COMPLETED

A Study to Evaluate the Effects of Stopping Maintenance Therapy for Cytomegalovirus (CMV) Retinitis After Effective Anti-HIV Therapy

Lead Sponsor:

National Institute of Allergy and Infectious Diseases (NIAID)

Conditions:

Cytomegalovirus Retinitis

HIV Infections

Eligibility:

All Genders

13+ years

Brief Summary

The purpose of this study is to see if it is safe to stop maintenance therapy in HIV-positive patients with treated and healed CMV retinitis (eye disease) who have responded well to anti-HIV (antiretr...

Detailed Description

This study proposes to assess the hypothesis that, in HIV-infected patients with treated and healed CMV retinitis, an increase in CD4+ T-cells after initiation of potent antiretroviral therapy is eith...

Eligibility Criteria

Inclusion Criteria

You may be eligible for this study if you:

  • Are HIV-positive.
  • Have a CD4 count greater than 100 cells/mm3.
  • Have healed CMV retinitis after receiving anti-CMV therapy for at least 8 weeks within 3 months prior to study entry.
  • Have taken antiretroviral therapy for at least 8 weeks prior to study entry; combination therapy must include at least 2 of the following: protease inhibitors (PIs), nucleoside reverse transcriptase inhibitors (NRTIs), or non-nucleoside reverse transcriptase inhibitors (NNRTIs).
  • Have a life expectancy of at least 6 months.
  • Are at least 13 years old (need consent if under 18).

Exclusion Criteria

You will not be eligible for this study if you:

  • Have any unstable or severe medical conditions that would keep you from completing the study.
  • Require chemotherapy or radiation therapy.
  • Have a history of certain eye disorders.

Key Trial Info

Start Date :

Trial Type :

OBSERVATIONAL

End Date :

Estimated Enrollment :

75 Patients enrolled

Trial Details

Trial ID

NCT00000905

Last Update

July 30 2008

Active Locations (25)

Enter a location and click search to find clinical trials sorted by distance.

Page 1 of 7 (25 locations)

1

Univ of Southern California / LA County USC Med Ctr

Los Angeles, California, United States, 900331079

2

UCLA CARE Ctr

Los Angeles, California, United States, 90095

3

Willow Clinic

Menlo Park, California, United States, 94025

4

Univ of California / San Diego Treatment Ctr

San Diego, California, United States, 921036325

A Study to Evaluate the Effects of Stopping Maintenance Therapy for Cytomegalovirus (CMV) Retinitis After Effective Anti-HIV Therapy | DecenTrialz