A prospective study of discontinuing primary and secondary Pneumocystis carinii pneumonia prophylaxis after CD4 cell count increase to > 200 x 106 /l.
S L Koletar, A E Heald, D Finkelstein...
https://pubmed.ncbi.nlm.nih.gov/11504983Completed
Age: 13Years +
All Genders
ID00000908
Impact of Discontinuing PCP Prophylaxis in Subjects Receiving Antiretroviral Therapies Who Have Had Increases in CD4 Counts to > 200 Cells/mm3
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2005-06-24
250
Participants Needed
54
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to see how often Pneumocystis carinii pneumonia (PCP) occurs in HIV-positive patients who have stopped taking medications that help prevent PCP. The risk of developing PCP may be decreased when an HIV-positive patient's CD4 cell counts (cells of the immune system which fight infection) are more than 200 cells/mm3. This study looks at whether it is acceptable to stop PCP prevention treatment in these patients.
CONDITIONS
Official Title
A Study to Evaluate the Impact of Stopping Treatment for the Prevention of Pneumonia in HIV-Positive Patients Receiving Anti-HIV Drugs Who Have Increased CD4 Cell Counts
Who Can Participate
Age: 13Years +
All Genders
Eligibility Criteria
You may qualify if you...
Inclusion Criteria
You may be eligible for this study if you:
- Are HIV-positive.
- Have had 1 CD4 cell count of less than 100 cells/mm3 and have never had PCP, or have had at least 2 CD4 cell counts over 200 cells/mm3 and have had PCP within 6 months prior to study entry.
- Have received PCP prevention medication within 3 months of study entry.
- Are at least 13 years old (need consent if under 18).
- Are taking anti-HIV (antiretroviral) medication at study entry.
Exclusion Criteria
You will not be eligible for this study if you:
- Have active PCP or symptoms of PCP within 2 weeks of study entry.
- Have a fever lasting more than 2 weeks.
- Have oral candidiasis (thrush).
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 54 locations
1
Univ of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Status Unknown
2
Kaiser Foundation Hosp
Harbor City, California, United States, 90710
Status Unknown
3
Kaiser Permanente LAMC
Los Angeles, California, United States, 90027
Status Unknown
4
Univ of Southern California / LA County USC Med Ctr
Los Angeles, California, United States, 900331079
Status Unknown
5
Willow Clinic
Menlo Park, California, United States, 94025
Status Unknown
6
Univ of California / San Diego Treatment Ctr
San Diego, California, United States, 921036325
Status Unknown
7
San Francisco AIDS Clinic / San Francisco Gen Hosp
San Francisco, California, United States, 941102859
Status Unknown
8
San Francisco Gen Hosp
San Francisco, California, United States, 941102859
Status Unknown
9
Santa Clara Valley Med Ctr / AIDS Community Rsch Consortium
San Jose, California, United States, 951282699
Status Unknown
10
Marin County Specialty Clinic
San Rafael, California, United States, 94903
Status Unknown
11
San Mateo AIDS Program / Stanford Univ
Stanford, California, United States, 943055107
Status Unknown
12
Stanford Univ Med Ctr
Stanford, California, United States, 943055107
Status Unknown
13
Univ of Colorado Health Sciences Ctr
Denver, Colorado, United States, 80262
Status Unknown
14
Howard Univ
Washington D.C., District of Columbia, United States, 20059
Status Unknown
15
Univ of Miami School of Medicine
Miami, Florida, United States, 331361013
Status Unknown
16
Emory Univ
Atlanta, Georgia, United States, 30308
Status Unknown
17
Queens Med Ctr
Honolulu, Hawaii, United States, 96816
Status Unknown
18
Univ of Hawaii / Leahi Hosp
Honolulu, Hawaii, United States, 96816
Status Unknown
19
Northwestern Univ Med School
Chicago, Illinois, United States, 60611
Status Unknown
20
Cook County Hosp
Chicago, Illinois, United States, 60612
Status Unknown
21
Rush Presbyterian - Saint Luke's Med Ctr
Chicago, Illinois, United States, 60612
Status Unknown
22
Louis A Weiss Memorial Hosp
Chicago, Illinois, United States, 60640
Status Unknown
23
Indiana Univ Hosp
Indianapolis, Indiana, United States, 462025250
Status Unknown
24
Division of Inf Diseases/ Indiana Univ Hosp
Indianapolis, Indiana, United States, 46202
Status Unknown
25
Methodist Hosp of Indiana / Life Care Clinic
Indianapolis, Indiana, United States, 46202
Status Unknown
26
Johns Hopkins Hosp
Baltimore, Maryland, United States, 21287
Status Unknown
27
Harvard (Massachusetts Gen Hosp)
Boston, Massachusetts, United States, 02114
Status Unknown
28
Boston Med Ctr
Boston, Massachusetts, United States, 02118
Status Unknown
29
Beth Israel Deaconess - West Campus
Boston, Massachusetts, United States, 02215
Status Unknown
30
Beth Israel Deaconess Med Ctr
Boston, Massachusetts, United States, 02215
Status Unknown
31
Univ of Minnesota
Minneapolis, Minnesota, United States, 55455
Status Unknown
32
St Louis Regional Hosp / St Louis Regional Med Ctr
St Louis, Missouri, United States, 63112
Status Unknown
33
Univ of Nebraska Med Ctr
Omaha, Nebraska, United States, 681985130
Status Unknown
34
SUNY / Erie County Med Ctr at Buffalo
Buffalo, New York, United States, 14215
Status Unknown
35
Beth Israel Med Ctr
New York, New York, United States, 10003
Status Unknown
36
Bellevue Hosp / New York Univ Med Ctr
New York, New York, United States, 10016
Status Unknown
37
Chelsea Ctr
New York, New York, United States, 10021
Status Unknown
38
Cornell Univ Med Ctr
New York, New York, United States, 10021
Status Unknown
39
Mount Sinai Med Ctr
New York, New York, United States, 10029
Status Unknown
40
St Mary's Hosp (Univ of Rochester/Infectious Diseases)
Rochester, New York, United States, 14642
Status Unknown
41
Univ of Rochester Medical Center
Rochester, New York, United States, 14642
Status Unknown
42
Univ of North Carolina
Chapel Hill, North Carolina, United States, 275997215
Status Unknown
43
Duke Univ Med Ctr
Durham, North Carolina, United States, 27710
Status Unknown
44
Univ of Cincinnati
Cincinnati, Ohio, United States, 452670405
Status Unknown
45
Univ of Kentucky Lexington
Cincinnati, Ohio, United States, 45267
Status Unknown
46
Case Western Reserve Univ
Cleveland, Ohio, United States, 44106
Status Unknown
47
MetroHealth Med Ctr
Cleveland, Ohio, United States, 441091998
Status Unknown
48
Ohio State Univ Hosp Clinic
Columbus, Ohio, United States, 432101228
Status Unknown
49
Philadelphia Veterans Administration Med Ctr
Philadelphia, Pennsylvania, United States, 19104
Status Unknown
50
Univ of Pennsylvania at Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Status Unknown
51
Univ of Pittsburgh Med Ctr
Pittsburgh, Pennsylvania, United States, 15213
Status Unknown
52
Julio Arroyo
West Columbia, South Carolina, United States, 29169
Status Unknown
53
Univ of Washington
Seattle, Washington, United States, 98104
Status Unknown
54
Univ of Puerto Rico
San Juan, Puerto Rico, 009365067
Status Unknown
Loading map...
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here