Status:
COMPLETED
A Study of the Effectiveness of Different Anti-HIV Treatments in HIV-Positive Individuals Who Have Been on a Protease Inhibitor-Containing Drug Regimen for at Least 16 Weeks
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
HIV Infections
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to compare different treatments for HIV infection to see which works best to lower HIV levels and to raise the number of CD4 cells (cells of the immune system that fight i...
Detailed Description
Current recommendations for the initial treatment of HIV infection have centered on the reduction of plasma HIV levels. It has been shown that a combination of 2 nucleoside reverse transcriptase inhib...
Eligibility Criteria
Inclusion Criteria
You may be eligible for this study if you:
- Are HIV-positive.
- Have an HIV RNA count of at least 400 copies/ml.
- Are at least 13 years old (need consent if under 18).
- Have been on antiretroviral treatment (including at least 2 NRTIs) for at least 16 weeks prior to study entry.
- Agree to practice abstinence or to use effective methods of birth control, including a barrier method, during the study.
Exclusion Criteria
You will not be eligible for this study if you:
- Are pregnant or breast-feeding.
- Have active opportunistic (HIV-associated) infections.
- Have taken nelfinavir (NFV) for more than 2 weeks after failing indinavir/ritonavir (IDV/RTV) treatment or have taken IDV/RTV for more than 2 weeks after failing NFV treatment.
- Have used any protease inhibitor other than NFV or IDV/RTV for more than 2 weeks.
- Have used any non-nucleoside reverse transcriptase inhibitor (NNRTI) for more than 1 week.
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
End Date :
June 1 2000
Estimated Enrollment :
800 Patients enrolled
Trial Details
Trial ID
NCT00000914
End Date
June 1 2000
Last Update
October 29 2021
Active Locations (15)
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1
Community Consortium / UCSF
San Francisco, California, United States, 94110
2
Denver CPCRA / Denver Public Hlth
Denver, Colorado, United States, 802044507
3
Washington Reg AIDS Prog / Dept of Infect Dis
Washington D.C., District of Columbia, United States, 20422
4
AIDS Research Consortium of Atlanta
Atlanta, Georgia, United States, 303081962