Status:
COMPLETED
Five-Drug Anti-HIV Treatment Followed by Treatment Interruption in Patients Who Have Recently Been Infected With HIV
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
HIV Infections
Eligibility:
All Genders
16+ years
Phase:
PHASE2
Brief Summary
This study will determine what effect taking a combination of five anti-HIV drugs during the early stage of HIV infection, then temporarily stopping them once or twice, may have on the amount of HIV v...
Detailed Description
Acute, primary HIV infection represents a potentially unique opportunity to eradicate the infection. Although plasma viral load rises rapidly, the dominant infecting virus is relatively uniform geneti...
Eligibility Criteria
Inclusion Criteria:
- Acute HIV infection (recently infected with HIV or recent seroconversion)
- Karnofsky status of 80 or greater within 14 days prior to study entry
- Acceptable methods of contraception
- Able and willing to give written informed consent
Exclusion Criteria:
- Previously received anti-HIV drugs
- Hepatitis within 30 days prior to study entry
- Pancreatitis within 120 days prior to study entry
- Radiation or chemotherapy within 30 days prior to study entry
- Certain medications within 14 days prior to study entry
- Experimental or investigational therapy within 30 days prior to study entry
- Illness (non-HIV infection, cancer, etc.) at the time of study entry
- Pregnant or breastfeeding
Key Trial Info
Start Date :
May 1 1999
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2006
Estimated Enrollment :
121 Patients enrolled
Trial Details
Trial ID
NCT00000940
Start Date
May 1 1999
End Date
October 1 2006
Last Update
October 29 2021
Active Locations (18)
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1
USC CRS
Los Angeles, California, United States, 90033
2
UCLA CARE Center CRS
Los Angeles, California, United States, 90035
3
Ucsd, Avrc Crs
San Diego, California, United States, 92103
4
Ucsf Aids Crs
San Francisco, California, United States, 94110