Inclusion Criteria

Concurrent Medication:

Allowed:

• Acute use (< 14 days) of acyclovir for Herpes simplex virus infection or ketoconazole for symptomatic Candida infections.

An additional group of up to 20 patients may be added to the study. Patients from ACTG 148 with a repeatedly negative delayed-type hypersensitivity (DTH) reaction who have reached their third dose of ID gp160 at 32 mcg and have failed to develop new proliferative response have the option, after a 2-month interval, to enter this protocol.

• They must meet inclusion and exclusion criteria that apply to this protocol.
• Patients with CD4 counts of 400 - 500 cells/mm3 must be informed of the recommended zidovudine (AZT) therapy and sign an informed consent statement declining AZT therapy.

Exclusion Criteria

Co-existing Condition:

Patients with the following conditions or symptoms are excluded:

• Fever of > 100 degrees F persisting for > 15 days in a 30-day interval without definable cause.
• Recurrent oral candidiasis.
• Multidermatomal herpes zoster.
• Biopsy-proven hairy leukoplakia.
• Fatigue/malaise of > 1 month duration that interferes with normal activities.
• Evidence of clinically significant central nervous system dysfunction as assessed by neurological exam.
• Involuntary weight loss > 10 lbs or 10 percent of normal weight in a 6 month interval.
• Diarrhea (> 3 stools/day) for more than 30 days without definable cause.

Concurrent Medication:

Excluded:

• Antiretroviral agents of proven or potential efficacy or any potential immunoenhancing or immunosuppressive drugs.

Patients with the following are excluded:

• Known hypersensitivity to insect cells or baculovirus.
• Abnormal chest x-ray taken within 3 months of study entry.
• Systemic symptoms thought to be due to HIV infection (other than lymphadenopathy). Evidence of clinically significant central nervous system dysfunction as assessed by neurological exam.
• Unwilling or unable to give written informed consent.

Prior Medication:

Excluded within 90 days of study entry:

• Zidovudine (AZT), didanosine (ddI), or any potential antiretroviral or immunomodulating agents.

Active substance abuse (either continuing daily alcohol abuse or intravenous drug use).