Inclusion Criteria

Patients who have a primary diagnosis of AIDS related complex (ARC) including lymphadenopathy syndrome (LAS), who are positive for HIV antibody, have a minimum life expectancy of 3 months, and have one or more of the following symptoms for = or > 30 days:

• Fever.
• Night sweats.
• Fatigue.
• Oral thrush.
• Hairy leukoplakia.
• Diarrhea.
• Weight loss < 10 percent.
• Patients must be able to sign a written informed consent form, which must be obtained prior to treatment.

Concurrent Medication:

Allowed:

• Acetaminophen for temperature rise of > 38.5 degrees C - 650 mg by mouth every 4 hours on an as needed basis.

Severe rigors may be treated (or prevented) with meperidine 50 mg IV on an as needed basis in the absence of systolic hypotension < 80 mm Hg.

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Exclusion Criteria

Co-existing Condition:

Patients with the following are excluded:

• Clinically significant cardiac disease - New York Heart Association Class II, III, or IV.
• Hemorrhagic diathesis (including hemophilia) or active bleeding disorder (e.g., genitourinary, gastrointestinal).
• Clinically apparent vascular disease (including a prior history of pulmonary embolus, deep venous thrombosis, or peripheral arterial occlusive disease).

Concurrent Medication:

Excluded:

• Medications required for the treatment of active cardiac disease including cardiac glycosides, antiarrhythmics and antianginal agents.
• Anticoagulants.
• Thrombolytic agents.
• Nonsteroidal anti-inflammatory drugs.
• Ongoing therapy with vasodilators.
• Aspirin.
• Corticosteroids.
• Antihistamines.
• Barbiturates.
• Excluded within 4 weeks of study entry:
• Antiviral chemotherapy.
• Immunotherapy.
• Excluded within 12 weeks of study entry:
• Suramin.

Patients with the following are excluded:

• AIDS-associated opportunistic infection.
• Lipoprotein disorders.
• Hemophilia.

Prior Medication:

Excluded:

• Interferon gamma.
• Tumor necrosis factor.