Inclusion Criteria

Patients must have:

• Normal history and physical exam.
• No identifiable high-risk behavior for HIV infection.
• Negative ELISA for HIV.
• Normal cell-mediated immune responses using Merieux skin test.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

• Significant evidence of depression.
• Positive syphilis serology (e.g., RPR) that is documented not to be a false positive or from a remote (> 6 months) treated infection.
• Circulating Hepatitis B antigenemia.
• More than two sexual partners, or sexual contact with a high-risk partner, within the past 6 months.

Patients with the following prior conditions are excluded:

• History of immunodeficiency, chronic illness, autoimmune disease, or use of immunosuppressive medications.
• Significant evidence of depression or under treatment for psychiatric problems within the past year.
• History of anaphylaxis or other adverse vaccine reactions.
• Syphilis, gonorrhea, or any other sexually transmitted diseases (including chlamydia or pelvic inflammatory disease) within the past 6 months.

Prior Medication:

Excluded:

• Immunoglobulin or vaccines within the past 2 months.
• Experimental agents within the past 30 days.

Prior Treatment:

Excluded:

• Blood transfusions or cryoprecipitates within the past 3 months.

Risk Behavior: Excluded:

• History of IV drug use within the past year.
• More than two sexual partners, or sexual contact with a high-risk partner, within the past 6 months.