Status:
COMPLETED
Treatment With Cidofovir for Children With Laryngeal Papillomatosis (Warts in the Throat)
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Papilloma
Eligibility:
All Genders
2-17 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to see what dose of the drug cidofovir is safe to treat laryngeal papillomatosis (warts in the throat which occur over and over) in children. Laryngeal papillomatosis is ...
Detailed Description
Your child will be assigned randomly (like tossing a coin) to receive either cidofovir or placebo (an inactive substance). Neither you nor your doctor will know which your child is receiving. Your chi...
Eligibility Criteria
Inclusion Criteria:
Your child may be eligible for this study if he/she:
- Has active laryngeal papillomatosis (warts in the throat) that requires 8 or more surgeries per year.
- Developed this infection before the age of 16.
- Is between the ages of 2 and 17 years with consent of parent or guardian.
Exclusion Criteria:
Your child will not be eligible for this study if he/she:
- Has a history of a prior malignancy (cancer), kidney disease, or immune system deficiency.
- Is HIV-positive.
- Is allergic to probenecid.
- Has received radiation therapy to the throat area or has received certain medications.
- Is pregnant or breast-feeding.
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
End Date :
November 1 2005
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT00001126
End Date
November 1 2005
Last Update
August 27 2010
Active Locations (1)
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1
NIAID/DMID/CASG Central Unit
Birmingham, Alabama, United States, 35294