Functional studies of epidermal Langerhans cells and blood monocytes in HIV-infected persons.
A Blauvelt, M Clerici, D R Lucey...
https://pubmed.ncbi.nlm.nih.gov/7897231Completed
All Genders
Healthy Volunteers
ID00001150
Induction of Suction Blisters in Patients With Urticaria, Blistering Diseases, Inflammatory Dermatoses and Neoplastic Disorders, and in Normal Volunteers
Led by National Cancer Institute (NCI) · Updated on 2008-03-04
2000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The use of a suction blister apparatus has facilitated study of the immunologic capacity of human epidermal cells. We have been able to prepare purified populations of these cells after blister formation. Specifically, using the blister tops, we are able to enrich for epidermal Langerhans cells which are very potent stimulators in antigen presenting assays. Thus, this normal volunteer study provides an important source of fresh epidermal tissue from which we can study normal epidermal Langerhans cell function. In addition, we have recently used blister roofs in important experimental models of HIV-1 transmission. There is no other method available for assessing the biologic function of freshly isolated Langerhans cells without altering their milieu. It is a very safe and effective way to obtain human epidermal samples.
CONDITIONS
Official Title
Induction of Suction Blisters in Patients With Urticaria, Blistering Diseases, Inflammatory Dermatoses and Neoplastic Disorders, and in Normal Volunteers
Who Can Participate
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
INCLUSION CRITERIA
Patients with urticaria of all types, blistering diseases, inflammatory dermatoses and neoplastic skin diseases.
Patients 18 years of age or older.
No pregnant women.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 1 location
1
National Cancer Institute (NCI)
Bethesda, Maryland, United States, 20892
Status Unknown
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Modulation of T cell responses to recall antigens presented by Langerhans cells in HIV-discordant identical twins by anti-interleukin (IL)-10 antibodies and IL-12.
A Blauvelt, C Chougnet, G M Shearer...
https://pubmed.ncbi.nlm.nih.gov/8617889Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection.
M Zaitseva, A Blauvelt, S Lee...
https://pubmed.ncbi.nlm.nih.gov/9396607