Status:
COMPLETED
Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Hypolipoproteinemia
Hypercholesterolemia
Eligibility:
All Genders
18-80 years
Brief Summary
Researchers plan to study the fat-rich particles, called lipoproteins, which circulate in the blood. This study is designed to improve understanding of normal, as well as abnormal, lipoprotein metabol...
Detailed Description
We propose to investigate human in vivo lipoprotein metabolism using radiolabeled apolipoproteins on plasma lipoproteins. Paired kinetic studies using dual-labeled iodinated lipoproteins and apolipopr...
Eligibility Criteria
- INCLUSION CRITERIA:
Subjects with new and undefined dyslipidemia-particularly familial disorders with extreme phenotypes.
Healthy normal volunteers - (18 years old or older) controls to investigate the formation of HDL for prebeta HDL.
Euthyroid.
EXCLUSION CRITERIA:
Healthy control volunteers are initially screened for secondary causes of hyperlipidemia and are excluded if they have any clinically significant laboratory abnormality (i.e., liver disease, disease, kidney disease, endocrine disease,), chronic medical problems (i.e., hypertension, migraines, inflammatory bowel, hepatitis, HIV) or require any chronic medications (i.e., acne, asthma).
The healthy control volunteers weight must fall within the current guidelines for ideal body weight.
Pregnant women.
Unwilling to follow metabolic diet.
Allergic to iodine.
Unable to sign consent form.
Key Trial Info
Start Date :
September 3 1976
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
759 Patients enrolled
Trial Details
Trial ID
NCT00001154
Start Date
September 3 1976
Last Update
May 7 2026
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892