• Subjects will be recruited from the NIH referral center, neurological and psychiatric clinics, from self or family referral in response to advertisements or from private physicians. Healthy volunteers will include subjects who are considered at-risk for the development of FTD or CBS and subjects who serve as normal controls matched for key characteristics with the patients.

INCLUSION CRITERIA FOR PATIENTS:

• Diagnosis of possible / probable FTD or CBS
• Caregiver willing and able to accept the responsibilities involved in the study

EXCLUSION CRITERIA:

• Pregnant women. Women of childbearing potential will be screened by history for the possibility of pregnancy and undergo a urine pregnancy test. These women will be excluded from the imaging portions of the protocol.
• Behavioral symptoms that would preclude the gathering of data for the study
• Other medical or social condition that would preclude participation in the opinion of the investigators