Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects.
D R Rubinow, M C Hoban, G N Grover...
https://pubmed.ncbi.nlm.nih.gov/2962499Completed
FEMALE
Healthy Volunteers
ID00001232
Pituitary Gonadotropin Response to GnRH Stimulation in Menstrual, Climacteric and, Menopause-Related Mood and Behavioral Disorders
Led by National Institute of Mental Health (NIMH) · Updated on 2008-03-04
140
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The normal menstrual cycle is produced by a series of hormonal signals that starts with the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. The hypothalamus is located in the brain and is often referred to as the master gland. GnRH then acts on the pituitary gland and causes it to release two hormones, follicle stimulating hormone (FSH) and lutenizng hormone (LH). LH and FSH act on the ovary and cause it to release the hormones directly involved in menstruation, estrogen and progesterone. The purpose of this research study is to evaluate the hypothalamic-pituitary-gonadal axis activity as measured by pituitary hormones, FSH and LH in response to intravenous doses of gonadotropin releasing hormone (GnRH) in menstrual cycle-related hormones.
CONDITIONS
Official Title
The Effect of GnRH on Pitutitary Hormones in Menstrual-Cycle Mood Related Disorders
Who Can Participate
FEMALE
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
Age 18-65.
Female.
Use of barrier methods of birth control.
Not pregnant.
Not taking ongoing medications.
No medical illnesses.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 1 location
1
National Institute of Mental Health (NIMH)
Bethesda, Maryland, United States, 20892
Status Unknown
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Basal and stimulated gonadotropin levels in the perimenopause.
P J Schmidt, P R Gindoff, D A Baron...
https://pubmed.ncbi.nlm.nih.gov/8828428The anterior pituitary response to a gonadotropin-releasing hormone challenge test in normal older reproductive-age women.
V Y Fujimoto, N A Klein, D E Battaglia...
https://pubmed.ncbi.nlm.nih.gov/8774283