Status:
TERMINATED
Inflammatory Responses in Normal Volunteers and Patients With Abnormal Immune Responses
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Healthy Volunteers
Abnormal Phagocyte Function
Eligibility:
All Genders
6-65 years
Brief Summary
This study will investigate the inflammatory response. People with abnormal regulation of inflammation and immune defects often have an exaggerated or depressed inflammatory response that results in p...
Detailed Description
Patients with abnormal regulation of inflammation and with host defense defects often have an exaggerated or depressed inflammatory response with resultant difficulty in healing of recurrent infection...
Eligibility Criteria
- INCLUSION CRITERIA - PATIENTS:
Patients having or thought to have an immune defect between the ages of 6 and 65 years (inclusive) are eligible to participate.
INCLUSION CRITERIA - NORMAL VOLUNTEERS:
Be a healthy adult of either sex and between the ages of 18 and 65 years old.
Weight greater than 110 pounds.
Not have any heart, lung, or kidney disease, or bleeding disorders.
Not have a history of viral hepatitis (B or C) since age 11.
Not have a history of intravenous injection drug use.
Not have a history of engaging in high-risk activities for exposure to the AIDS virus.
Not be pregnant.
EXCLUSION CRITERIA - PATIENTS:
Patients less than 6 or greater than 65 years of age.
EXCLUSION CRITERIA - NORMAL VOLUNTEER:
Less than 18 years old or older than 65 years.
Have viral hepatitis (B or C).
HIV positive.
Receiving chemotherapeutic agent(s), or have underlying malignancy.
Pregnant.
Have history of heart, lung, kidney disease, or bleeding disorders.
Key Trial Info
Start Date :
April 24 1990
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 2 2019
Estimated Enrollment :
169 Patients enrolled
Trial Details
Trial ID
NCT00001257
Start Date
April 24 1990
End Date
August 2 2019
Last Update
August 6 2019
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892