Status:
COMPLETED
Ovarian Follicle Function in Patients With Primary Ovarian Failure
Lead Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Amenorrhea
Hypoaldosteronism
Eligibility:
FEMALE
18-42 years
Brief Summary
No proven therapy to restore ovarian function and fertility is available to patients with karyotypically normal spontaneous premature ovarian failure. We know that one-half of these patients have prim...
Detailed Description
No proven therapy to restore ovarian function and fertility is available to patients with karyotypically normal spontaneous primary ovarian insufficiency. We know that more than one-half of these pati...
Eligibility Criteria
- INCLUSION CRITERIA:
Women 18 to 42 years of age with primary ovarian insufficiency who meet the following requirements were candidates for recruitment to the study: 1) at least a four month history of oligo-amenorrhea not due to pregnancy, and 2) clearly elevated gonadotropins in the menopausal range on two separate occasions at least one month apart.
EXCLUSION CRITERIA:
Women with evidence for karyotypic, metabolic, toxic, or iatrogenic cause of the ovarian insufficiency were not candidates.
Key Trial Info
Start Date :
May 12 1991
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 8 2017
Estimated Enrollment :
1134 Patients enrolled
Trial Details
Trial ID
NCT00001275
Start Date
May 12 1991
End Date
February 8 2017
Last Update
October 6 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892