Completed

Age: 18Years - 42Years
FEMALE
ID00001275

Ovarian Follicle Function in Patients With Primary Ovarian Insufficiency

Led by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Updated on 2017-10-06

1134

Participants Needed

1

Research Sites

N/A

Total Duration

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AI-Summary

What this Trial Is About

No proven therapy to restore ovarian function and fertility is available to patients with karyotypically normal spontaneous premature ovarian failure. We know that one-half of these patients have primordial follicles remaining in the ovary, and these follicles can function intermittently. This is a diagnostic omnibus protocol that permits baseline clinical evaluation of patients with prematurem ovarian failure. The findings will determine patients' suitability for specifically focused therapeutic research protocols.

CONDITIONS

Official Title

Ovarian Follicle Function in Patients With Primary Ovarian Failure

Who Can Participate

Age: 18Years - 42Years
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • INCLUSION CRITERIA:

Women 18 to 42 years of age with primary ovarian insufficiency who meet the following requirements were candidates for recruitment to the study: 1) at least a four month history of oligo-amenorrhea not due to pregnancy, and 2) clearly elevated gonadotropins in the menopausal range on two separate occasions at least one month apart.

EXCLUSION CRITERIA:

Women with evidence for karyotypic, metabolic, toxic, or iatrogenic cause of the ovarian insufficiency were not candidates.

Not Eligible

You will not qualify if you...

History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety

Trial Site Locations

Total: 1 location

1

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, United States, 20892

Status Unknown

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How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Published Research Related To This Trial

Development of luteinized graafian follicles in patients with karyotypically normal spontaneous premature ovarian failure.

L M Nelson, J N Anasti, L M Kimzey...

https://pubmed.ncbi.nlm.nih.gov/7962345