Status:
COMPLETED
Establishing the Physiology of Syringomyelia
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Arnold Chiari Deformity
Hydrocephalus
Eligibility:
All Genders
18+ years
Brief Summary
The brain and spinal cord are surrounded by fluid called cerebrospinal fluid (CSF). The CSF flows through channels in the brain and around the spinal cord. Occasionally, people are born with malformat...
Detailed Description
The purpose of this study is to establish the mechanism of development and progression of syringomyelia. Although syringomyelia usually accompanies anatomic abnormalities at the craniocervical junctio...
Eligibility Criteria
- INCLUSION CRITERIA:
To be eligible to participate in this research study, the subject must:
Be 18 years of age or older.
Have syringomyelia.
Have a lesion that narrows the space for spinal fluid at the base of the skull or neck. Prior surgery for syringomyelia does not result in exclusion from the study if there is radiographic evidence of a syrinx and there is evidence of neurological deterioration related to the syrinx.
Be able to give informed consent.
EXCLUSION CRITERIA:
The subject will not be eligible to participate in this research study if the subject:
Is pregnant (because X-rays might injure a fetus).
Cannot have an MRI scan as determined by the radiologist.
Has a problem with bleeding that cannot be corrected.
Is unable to understand the risks of the testing and surgical therapy.
Has a blood test for HIV (the virus that causes AIDS) that is positive, because a positive HIV test would increase the risk of infection from research testing.
Key Trial Info
Start Date :
July 29 1992
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 31 2011
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00001327
Start Date
July 29 1992
End Date
March 31 2011
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892