Status:
COMPLETED
The Effects of Hormones in Growth Hormone-Treated Girls With Turner Syndrome
Lead Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Dwarfism
Turner's Syndrome
Eligibility:
FEMALE
10-14 years
Phase:
PHASE2
Brief Summary
Turners Syndrome is a genetic condition in females that is a result of abnormal chromosomes. Patients with Turner syndrome are typically short, have abnormal physical features, and lack the physical c...
Detailed Description
Turner syndrome is associated with short stature, multiple physical stigmata, and absent pubertal development. We propose to: (1) examine the effects of sex steroids (androgen) on multiple variables (...
Eligibility Criteria
- INCLUSION CRITERIA:
Girls with Turner syndrome will qualify to participate in this study if they meet the following criteria:
Karyotype diagnosis compatible with Turner syndrome.
No treatment with estrogen, androgen or growth hormone exceeding twelve months, and no treatment with either of these agents in the preceding 3 months.
Chronological age of 10.0 to 14.9 years.
Bone age less than or equal to 12 years.
EXCLUSION CRITERIA:
Prior treatment with estrogen, androgen, or growth hormone for more than twelve months.
Y component in peripheral karyotype.
Key Trial Info
Start Date :
December 11 1992
Trial Type :
INTERVENTIONAL
End Date :
October 10 2007
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00001343
Start Date
December 11 1992
End Date
October 10 2007
Last Update
July 2 2017
Active Locations (2)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
2
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107-6541